IFOM Publications 2015 « Research
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Publications 2015

Chronological order - last update April 2016
  1. Blood circulating tumor DNA for non-invasive genotyping of colon cancer patients.
    Siravegna G, Bardelli A.
    Mol Oncol. 2016 Mar;10(3):475-480. doi: 10.1016/j.molonc.2015.12.005. Epub 2015 Dec 17. Review.
    [PMID: 26774880] IF 5,331

  2. Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer.
    Russo M, Siravegna G, Blaszkowsky LS, Corti G, Crisafulli G, Ahronian LG, Mussolin B, Kwak EL, Buscarino M, Lazzari L, Valtorta E, Truini M, Jessop NA, Robinson HE, Hong TS, Mino-Kenudson M, Di Nicolantonio F, Thabet A, Sartore-Bianchi A, Siena S, Iafrate AJ, Bardelli A, et al.
    Cancer Discov. 2016 Feb;6(2):147-53. doi: 10.1158/2159-8290.CD-15-1283. Epub 2015 Dec 7.
    [PMID: 26644315] IF 19,453

  3. SUMO-mediated global and local control of recombination.
    Urulangodi M, Szakal B, Branzei D.
    Cell Cycle. 2016 Jan 17;15(2):160-1. doi: 10.1080/15384101.2015.1118918. Epub 2015 Nov 20.
    [PMID: 26587752] IF 4,565

  4. Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: a pooled analysis of 42,510 cases and 40,577 controls from the Breast Cancer Association Consortium.
    Lei J, Rudolph A, Moysich KB, Behrens S, Goode EL, Bolla MK, Dennis J, Dunning AM, Easton DF, Wang Q, Benitez J, Hopper JL, Southey MC, Schmidt MK, Broeks A, Fasching PA, Haeberle L, Peto J, Dos-Santos-Silva I, Sawyer EJ, Tomlinson I, Burwinkel B, et al.
    Hum Genet. 2016 Jan;135(1):137-54. doi: 10.1007/s00439-015-1616-8. Epub 2015 Nov 30
    [PMID: 26621531] IF 7,8580

  5. Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer.
    Russo M, Misale S, Wei G, Siravegna G, Crisafulli G, Lazzari L, Corti G, Rospo G, Novara L, Mussolin B, Bartolini A, Cam N, Patel R, Yan S, Shoemaker R, Wild R, Di Nicolantonio F, Bianchi AS, Li G, Siena S, Bardelli A.
    Cancer Discov. 2016 Jan;6(1):36-44. doi: 10.1158/2159-8290.CD-15-0940. Epub 2015 Nov 6.
    [PMID: 26546295] IF 19,453

  6. Coordinate regulation of microenvironmental stimuli and role of methylation in bone metastasis from breast carcinoma.
    Matteucci E, Maroni P, Disanza A, Bendinelli P, Desiderio MA.
    Biochim Biophys Acta. 2016 Jan;1863(1):64-76. doi: 10.1016/j.bbamcr.2015.10.010. Epub 2015 Oct 19
    [PMID: 26481505] IF 5,019

  7. Lamellipodial tension, not integrin/ligand binding, is the crucial factor to realise integrin activation and cell migration.
    Schulte C, Ferraris GM, Oldani A, Galluzzi M, Podestà A, Puricelli L, de Lorenzi V, Lenardi C, Milani P, Sidenius N.
    Eur J Cell Biol. 2016 Jan;95(1):1-14. doi: 10.1016/j.ejcb.2015.10.002. Epub 2015 Oct 19.
    [PMID: 26546295] IF 3,825

  8. G2/M chromosome transactions essentially relying on Smc5/6.
    Branzei D, Menolfi D.
    Cell Cycle. 2015 Dec 22:1-2. [Epub ahead of print]
    [PMID: 26694861] IF 4,565

  9. The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling.
    Giampietro C, Disanza A, Bravi L, Barrios-Rodiles M, Corada M, Frittoli E, Savorani C, Lampugnani MG, Boggetti B, Niessen C, Wrana JL, Scita G, Dejana E.
    J Cell Biol. 2015 Dec 21;211(6):1177-92. doi: 10.1083/jcb.201501089. Epub 2015 Dec 14.
    [PMID: 26668327] IF 9,834

  10. Essential Roles of the Smc5/6 Complex in Replication through Natural Pausing Sites and Endogenous DNA Damage Tolerance.
    Menolfi D, Delamarre A, Lengronne A, Pasero P, Branzei D.
    Mol Cell. 2015 Dec 17;60(6):835-46. doi: 10.1016/j.molcel.2015.10.023. Epub 2015 Nov 19.
    [PMID: 26698660] IF 14,018

  11. Exploring and exploiting the systemic effects of deregulated replication licensing.
    Petrakis TG, Komseli ES, Papaioannou M, Vougas K, Polyzos A, Myrianthopoulos V, Mikros E, Trougakos IP, Thanos D, Branzei D, Townsend P, Gorgoulis VG.
    Semin Cancer Biol. 2015 Dec 17. doi:pii: S1044-579X(15)30003-1. 10.1016/j.semcancer.2015.12.002. [Epub ahead of print] Review.
    [PMID: 26707000] IF 9,33

  12. The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin.
    Brunati M, Perucca S, Han L, Cattaneo A, Consolato F, Andolfo A, Schaeffer C, Olinger E, Peng J, Santambrogio S, Perrier R, Li S, Bokhove M, Bachi A, Hummler E, Devuyst O, Wu Q, Jovine L, Rampoldi L.
    Elife. 2015 Dec 17;4. doi:pii: e08887. 10.7554/eLife.08887.
    [PMID: 26673890] IF 9,322

  13. Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis.
    Tricarico R, Cortellino S, Riccio A, Jagmohan-Changur S, Van der Klift H, Wijnen J, Turner D, Ventura A, Rovella V, Percesepe A, Lucci-Cordisco E, Radice P, Bertario L, Pedroni M, Ponz de Leon M, Mancuso P, Devarajan K, Cai KQ, Klein-Szanto AJ, Neri G, Møller P, Viel A, et al.
    Oncotarget. 2015 Dec 15;6(40):42892-904. doi: 10.18632/oncotarget.5740.
    [PMID: 26503472] IF 6,359

  14. Identification of linc-NeD125, a novel long non coding RNA that hosts miR-125b-1 and negatively controls proliferation of human neuroblastoma cells.
    Bevilacqua V, Gioia U, Di Carlo V, Tortorelli AF, Colombo T, Bozzoni I, Laneve P, Caffarelli E.
    RNA Biol. 2015 Dec 2;12(12):1323-37. doi: 10.1080/15476286.2015.1096488.
    [PMID: 26480000] IF 4,974

  15. ATM and ATR signaling at a glance.
    Awasthi P, Foiani M, Kumar A.
    J Cell Sci. 2015 Dec 1;128(23):4255-62. doi: 10.1242/jcs.169730. Epub 2015 Nov 13. Review.
    [PMID: 26567218] IF 5,432

  16. Fasting plus tyrosine kinase inhibitors in cancer.
    Caffa I, Longo VD, Nencioni A.
    Aging (Albany NY). 2015 Dec;7(12):1026-7.
    [PMID: 26645151] IF 6,432

  17. Nanosensors for early cancer detection and for therapeutic drug monitoring.
    Salvati E, Stellacci F, Krol S.
    Nanomedicine (Lond). 2015 Dec;10(23):3495-512. doi: 10.2217/nnm.15.180. Epub 2015 Nov 26.
    [PMID: 26606949] IF 5,413

  18. The Effects of miR-20a on p21: Two Mechanisms Blocking Growth Arrest in TGF-β- Responsive Colon Carcinoma.
    Sokolova V, Fiorino A, Zoni E, Crippa E, Reid JF, Gariboldi M, Pierotti MA.
    J Cell Physiol. 2015 Dec;230(12):3105-14. doi: 10.1002/jcp.25051.
    [PMID: 26012475] IF 3,839

  19. Mapping the topographic epitope landscape on the urokinase plasminogen activator receptor (uPAR) by surface plasmon resonance and X-ray crystallography.
    Zhao B, Gandhi S, Yuan C, Luo Z, Li R, Gårdsvoll H, de Lorenzi V, Sidenius N, Huang M, Ploug M.
    Data Brief. 2015 Dec;5:107-13. doi: 10.1016/j.dib.2015.08.027.
    [PMID: 26504891]

  20. KLF4 is a key determinant in the development and progression of cerebral cavernous malformations.
    Cuttano R, Rudini N, Bravi L, Corada M, Giampietro C, Papa E, Morini MF, Maddaluno L, Baeyens N, Adams RH, Jain MK, Owens GK, Schwartz M, Lampugnani MG, Dejana E.
    EMBO Mol Med. 2015 Nov 26;8(1):6-24. doi: 10.15252/emmm.201505433.
    [PMID: 26612856] IF 8,665

  21. The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells.
    Tosoni D, Zecchini S, Coazzoli M, Colaluca I, Mazzarol G, Rubio A, Caccia M, Villa E, Zilian O, Di Fiore PP, Pece S.
    J Cell Biol. 2015 Nov 23;211(4):845-62. doi: 10.1083/jcb.201505037.
    [PMID: 26598619] IF 9,834

  22. Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1.
    Mazzieri R, Pietrogrande G, Gerasi L, Gandelli A, Colombo P, Moi D, Brombin C, Ambrosi A, Danese S, Mignatti P, Blasi F, D'Alessio S.
    Cancer Res. 2015 Nov 15;75(22):4895-909. doi: 10.1158/0008-5472.CAN-15-0378. Epub 2015 Nov 2.
    [PMID: 26527290] IF 9,239

  23. Non-Coding RNA: Sequence-Specific Guide for Chromatin Modification and DNA Damage Signaling.
    Francia S.
    Front Genet. 2015;6:320. doi: 10.3389/fgene.2015.00320. Review.
    [PMID: 26617633]

  24. A gut-vascular barrier controls the systemic dissemination of bacteria.
    Spadoni I, Zagato E, Bertocchi A, Paolinelli R, Hot E, Di Sabatino A, Caprioli F, Bottiglieri L, Oldani A, Viale G, Penna G, Dejana E, Rescigno M.
    Science. 2015 Nov 13;350(6262):830-4. doi: 10.1126/science.aad0135.
    [PMID: 26564856] IF 33,611

  25. Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer.
    Sartore-Bianchi A, Ardini E, Bosotti R, Amatu A, Valtorta E, Somaschini A, Raddrizzani L, Palmeri L, Banfi P, Bonazzina E, Misale S, Marrapese G, Leone A, Alzani R, Luo D, Hornby Z, Lim J, Veronese S, Vanzulli A, Bardelli A, Martignoni M, Davite C, et al.
    J Natl Cancer Inst. 2015 Nov 12;108(1). doi:pii: djv306. 10.1093/jnci/djv306. Print 2016 Jan.
    [PMID: 26563355] IF 12,583

  26. miR-17-92 fine-tunes MYC expression and function to ensure optimal B cell lymphoma growth.
    Mihailovich M, Bremang M, Spadotto V, Musiani D, Vitale E, Varano G, Zambelli F, Mancuso FM, Cairns DA, Pavesi G, Casola S, Bonaldi T.
    Nat Commun. 2015 Nov 10;6:8725. doi: 10.1038/ncomms9725.
    [PMID: 26555894] IF 11,47

  27. Visual detection of Flavivirus RNA in living cells.
    Miorin L, Maiuri P, Marcello A.
    Methods. 2015 Nov 2. doi:pii: S1046-2023(15)30140-7. 10.1016/j.ymeth.2015.11.002. [Epub ahead of print]
    [PMID: 26542763] IF 3,645

  28. Differential DNA damage signalling and apoptotic threshold correlate with mouse epiblastspecific hypersensitivity to radiation.
    Laurent A, Blasi F.
    Development. 2015 Nov 1;142(21):3675-85. doi: 10.1242/dev.125708. Epub 2015 Sep 22.
    [PMID: 26395482] IF 6,462

  29. Novel and known genetic variants for male breast cancer risk at 8q24.21, 9p21.3, 11q13.3 and 14q24.1: results from a multicenter study in Italy.
    Silvestri V, Rizzolo P, Scarnó M, Chillemi G, Navazio AS, Valentini V, Zelli V, Zanna I, Saieva C, Masala G, Bianchi S, Manoukian S, Barile M, Pensotti V, Peterlongo P, Varesco L, Tommasi S, Russo A, Giannini G, Cortesi L, Viel A, Montagna M, et al.
    Eur J Cancer. 2015 Nov;51(16):2289-95. doi: 10.1016/j.ejca.2015.07.020. Epub 2015 Aug 3.
    [PMID: 26248686] IF 5,417

  30. Fine-scale mapping of the 4q24 locus identifies two independent loci associated with breast cancer risk.
    Guo X, Long J, Zeng C, Michailidou K, Ghoussaini M, Bolla MK, Wang Q, Milne RL, Shu XO, Cai Q, Beesley J, Kar SP, Andrulis IL, Anton-Culver H, Arndt V, Beckmann MW, Beeghly-Fadiel A, Benitez J, Blot W, Bogdanova N, Bojesen SE, Brauch H, et al.
    Cancer Epidemiol Biomarkers Prev. 2015 Nov;24(11):1680-91. doi: 10.1158/1055-9965.EPI-15-0363. Epub 2015 Sep 9.
    ó [PMID: 26354892] IF 4,125

  31. Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
    Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK, Sulem P, Bulik-Sullivan B, Esko T, Johnson AD, Elks CE, Franceschini N, He C, Altmaier E, Brody JA, Franke LL, Huffman JE, Keller MF, McArdle PF, Nutile T, et al.
    Nat Genet. 2015 Nov;47(11):1294-303. doi: 10.1038/ng.3412. Epub 2015 Sep 28.
    [PMID: 26414677] IF 29,352

  32. Novel localization of formin mDia2: importin Β-mediated delivery to and retention at the cytoplasmic side of the nuclear envelope.
    Shao X, Kawauchi K, Shivashankar GV, Bershadsky AD.
    Biol Open. 2015 Oct 30;4(11):1569-75. doi: 10.1242/bio.013649.
    [PMID: 26519515] IF 2,416

  33. Constitutional de novo deletion of the FBXW7 gene in a patient with focal segmental glomerulosclerosis and multiple primitive tumors.
    Roversi G, Picinelli C, Bestetti I, Crippa M, Perotti D, Ciceri S, Saccheri F, Collini P, Poliani PL, Catania S, Peissel B, Pagni F, Russo S, Peterlongo P, Manoukian S, Finelli P.
    Sci Rep. 2015 Oct 20;5:15454. doi: 10.1038/srep15454.
    [PMID: 26482194] IF 5,578

  34. The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis.
    Nakasaki M, Hwang Y, Xie Y, Kataria S, Gund R, Hajam EY, Samuel R, George R, Danda D, M J P, Nakamura T, Shen Z, Briggs S, Varghese S, Jamora C.
    Nat Commun. 2015 Oct 15;6:8574. doi: 10.1038/ncomms9574.
    [PMID: 26469761] IF 11,47

  35. Rtt107 Is a Multi-functional Scaffold Supporting Replication Progression with Partner SUMO and Ubiquitin Ligases.
    Hang LE, Peng J, Tan W, Szakal B, Menolfi D, Sheng Z, Lobachev K, Branzei D, Feng W, Zhao X.
    Mol Cell. 2015 Oct 15;60(2):268-79. doi: 10.1016/j.molcel.2015.08.023. Epub 2015 Oct 1.
    [PMID: 26439300] IF 14,018

  36. Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth.
    Setti M, Osti D, Richichi C, Ortensi B, Del Bene M, Fornasari L, Beznoussenko G, Mironov A, Rappa G, Cuomo A, Faretta M, Bonaldi T, Lorico A, Pelicci G.
    Oncotarget. 2015 Oct 13;6(31):31413-27. doi: 10.18632/oncotarget.5105.
    [PMID: 26429879] IF 6,359

  37. The alternative splicing factor Nova2 regulates vascular development and lumen formation.
    Giampietro C, Deflorian G, Gallo S, Di Matteo A, Pradella D, Bonomi S, Belloni E, Nyqvist D, Quaranta V, Confalonieri S, Bertalot G, Orsenigo F, Pisati F, Ferrero E, Biamonti G, Fredrickx E, Taveggia C, Wyatt CD, Irimia M, Di Fiore PP, Blencowe BJ, Dejana E, et al.
    Nat Commun. 2015 Oct 8;6:8479. doi: 10.1038/ncomms9479.
    [PMID: 26446569] IF 11,47

  38. Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress.
    Rossi SE, Ajazi A, Carotenuto W, Foiani M, Giannattasio M.
    Cell Rep. 2015 Oct 6;13(1):80-92. doi: 10.1016/j.celrep.2015.08.073. Epub 2015 Sep 24.
    [PMID: 26411679] IF 8,358

  39. Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication.
    Urulangodi M, Sebesta M, Menolfi D, Szakal B, Sollier J, Sisakova A, Krejci L, Branzei D.
    Genes Dev. 2015 Oct 1;29(19):2067-80. doi: 10.1101/gad.265629.115.
    [PMID: 26443850] IF 10,798

  40. PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs.
    Prahallad A, Heynen GJ, Germano G, Willems SM, Evers B, Vecchione L, Gambino V, Lieftink C, Beijersbergen RL, Di Nicolantonio F, Bardelli A, Bernards R.
    Cell Rep. 2015 Sep 29;12(12):1978-85. doi: 10.1016/j.celrep.2015.08.037. Epub 2015 Sep 10.
    [PMID: 26365186] IF 8,358

  41. Defective autophagy is a key feature of cerebral cavernous malformations.
    Marchi S, Corricelli M, Trapani E, Bravi L, Pittaro A, Delle Monache S, Ferroni L, Patergnani S, Missiroli S, Goitre L, Trabalzini L, Rimessi A, Giorgi C, Zavan B, Cassoni P, Dejana E, Retta SF, Pinton P.
    EMBO Mol Med. 2015 Sep 28;7(11):1403-17. doi: 10.15252/emmm.201505316.
    [PMID: 26417067] IF 8,665

  42. Tumorigenesis by Meis1 overexpression is accompanied by a change of DNA target-sequence specificity which allows binding to the AP-1 element.
    Dardaei L, Penkov D, Mathiasen L, Bora P, Morelli MJ, Blasi F.
    Oncotarget. 2015 Sep 22;6(28):25175-87. doi: 10.18632/oncotarget.4488.
    [PMID: 26259236] IF 6,359

  43. Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers.
    Misale S, Bozic I, Tong J, Peraza-Penton A, Lallo A, Baldi F, Lin KH, Truini M, Trusolino L, Bertotti A, Di Nicolantonio F, Nowak MA, Zhang L, Wood KC, Bardelli A.
    Nat Commun. 2015 Sep 22;6:8305. doi: 10.1038/ncomms9305.
    [PMID: 26392303] IF 11,47

  44. FANCM c.5791C>T nonsense mutation (rs144567652) induces exon skipping, affects DNA repair activity and is a familial breast cancer risk factor.
    Peterlongo P, Catucci I, Colombo M, Caleca L, Mucaki E, Bogliolo M, Marin M, Damiola F, Bernard L, Pensotti V, Volorio S, Dall'Olio V, Meindl A, Bartram C, Sutter C, Surowy H, Sornin V, Dondon MG, Eon- Marchais S, Stoppa-Lyonnet D, Andrieu N, Sinilnikova OM; et al.
    Hum Mol Genet. 2015 Sep 15;24(18):5345-55. doi: 10.1093/hmg/ddv251. Epub 2015 Jun 30.
    [PMID: 26130695] IF 6,393

  45. Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer.
    Barault L, Amatu A, Bleeker FE, Moutinho C, Falcomatà C, Fiano V, Cassingena A, Siravegna G, Milione M, Cassoni P, De Braud F, Rudà R, Soffietti R, Venesio T, Bardelli A, Wesseling P, de Witt Hamer P, Pietrantonio F, Siena S, Esteller M, Sartore-Bianchi A, Di Nicolantonio F.
    Ann Oncol. 2015 Sep;26(9):1994-9. doi: 10.1093/annonc/mdv272. Epub 2015 Jun 25.
    [PMID: 26113646] IF 7,04

  46. DPD and UGT1A1 deficiency in colorectal cancer patients receiving triplet chemotherapy with fluoropyrimidines, oxaliplatin and irinotecan.
    Falvella FS, Cheli S, Martinetti A, Mazzali C, Iacovelli R, Maggi C, Gariboldi M, Pierotti MA, Di Bartolomeo M, Sottotetti E, Mennitto R, Bossi I, de Braud F, Clementi E, Pietrantonio F.
    Br J Clin Pharmacol. 2015 Sep;80(3):581-8. doi: 10.1111/bcp.12631. Epub 2015 Jun 22.
    [PMID: 25782327] IF 3,878

  47. Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells.
    Capuani F, Conte A, Argenzio E, Marchetti L, Priami C, Polo S, Di Fiore PP, Sigismund S, Ciliberto A.
    Nat Commun. 2015 Aug 12;6:7999. doi: 10.1038/ncomms8999.
    [PMID: 26264748] IF 11,47

  48. Retention of the Native Epigenome in Purified Mammalian Chromatin.
    Ehrensberger AH, Franchini DM, East P, George R, Matthews N, Maslen SL, Svejstrup JQ.
    PLoS One. 2015;10(8):e0133246. doi: 10.1371/journal.pone.0133246. Erratum in: PLoS One. 2015;10(10):e0141250.
    [PMID: 26248330] IF 3,234

  49. Liquid biopsies to evaluate early therapeutic response in colorectal cancer.
    Montagut C, Siravegna G, Bardelli A.
    Ann Oncol. 2015 Aug;26(8):1525-7. doi: 10.1093/annonc/mdv228. Epub 2015 May 12.
    [PMID: 25969369] IF 7,04

  50. Interventions to Slow Aging in Humans: Are We Ready?
    Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, et al.
    Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22.
    [PMID: 25902704] IF 6,34

  51. Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae.
    Manfrini N, Clerici M, Wery M, Colombo CV, Descrimes M, Morillon A, d'Adda di Fagagna F, Longhese MP.
    Elife. 2015 Jul 31;4. doi: 10.7554/eLife.08942.
    [PMID: 26231041] IF 9,322

  52. Lessons from the first ecancer symposium on angiogenesis in gastric cancer.
    Nailor A, Dejana E, Reynolds AR, Punwani S, Curigliano G, Bertolini F, Shah M, Danesi R, Kerbel R, McVie G.
    Ecancermedicalscience. 2015;9:553. doi: 10.3332/ecancer.2015.553.
    [PMID: 26284117]

  53. The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma.
    Di Cristofori A, Ferrero S, Bertolini I, Gaudioso G, Russo MV, Berno V, Vanini M, Locatelli M, Zavanone M, Rampini P, Vaccari T, Caroli M, Vaira V.
    Oncotarget. 2015 Jul 10;6(19):17514-31.
    [PMID: 26020805] IF 6,359

  54. CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination.
    Marjanović M, Sánchez-Huertas C, Terré B, Gómez R, Scheel JF, Pacheco S, Knobel PA, Martínez-Marchal A, Aivio S, Palenzuela L, Wolfrum U, McKinnon PJ, Suja JA, Roig I, Costanzo V, Lüders J, Stracker TH.
    Nat Commun. 2015 Jul 9;6:7676. doi: 10.1038/ncomms8676.
    [PMID: 26158450] IF 11,47

  55. Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells.
    Cremaschi P, Oliverio M, Leva V, Bione S, Carriero R, Mazzucco G, Palamidessi A, Scita G, Biamonti G, Montecucco A.
    PLoS One. 2015;10(7):e0130561. doi: 10.1371/journal.pone.0130561.
    [PMID: 26151554] IF 3,234

  56. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.
    Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, et al.
    Cell Metab. 2015 Jul 7;22(1):86-99. doi: 10.1016/j.cmet.2015.05.012. Epub 2015 Jun 18.
    [PMID: 26094889] IF 17,565

  57. Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice.
    Bravi L, Rudini N, Cuttano R, Giampietro C, Maddaluno L, Ferrarini L, Adams RH, Corada M, Boulday G, Tournier-Lasserve E, Dejana E, Lampugnani MG.
    Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8421-6. doi: 10.1073/pnas.1501352112. Epub 2015 Jun 24.
    [PMID: 26109568] IF 9,674

  58. Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression.
    Darabi H, McCue K, Beesley J, Michailidou K, Nord S, Kar S, Humphreys K, Thompson D, Ghoussaini M, Bolla MK, Dennis J, Wang Q, Canisius S, Scott CG, Apicella C, Hopper JL, Southey MC, Stone J, Broeks A, Schmidt MK, Scott RJ, Lophatananon A, et al.
    Am J Hum Genet. 2015 Jul 2;97(1):22-34. doi: 10.1016/j.ajhg.2015.05.002. Epub 2015 Jun 11.
    [PMID: 26073781] IF 10,931

  59. Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.
    Siravegna G, Mussolin B, Buscarino M, Corti G, Cassingena A, Crisafulli G, Ponzetti A, Cremolini C, Amatu A, Lauricella C, Lamba S, Hobor S, Avallone A, Valtorta E, Rospo G, Medico E, Motta V, Antoniotti C, Tatangelo F, Bellosillo B, Veronese S, Budillon A, et al.
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  60. Alternative Okazaki Fragment Ligation Pathway by DNA Ligase III.
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    Genes (Basel). 2015 Jun 23;6(2):385-98. doi: 10.3390/genes6020385. Review.
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  61. Vascular endothelial growth factor C disrupts the endothelial lymphatic barrier to promote colorectal cancer invasion.
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    Gastroenterology. 2015 Jun;148(7):1438-51.e8. doi: 10.1053/j.gastro.2015.03.005. Epub 2015 Mar 6.
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  62. Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models.
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  63. Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition.
    Caffa I, D'Agostino V, Damonte P, Soncini D, Cea M, Monacelli F, Odetti P, Ballestrero A, Provenzani A, Longo VD, Nencioni A.
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  64. Mechanical stimulation induces formin-dependent assembly of a perinuclear actin rim.
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  65. Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2.
    Orr N, Dudbridge F, Dryden N, Maguire S, Novo D, Perrakis E, Johnson N, Ghoussaini M, Hopper JL, Southey MC, Apicella C, Stone J, Schmidt MK, Broeks A, Van't Veer LJ, Hogervorst FB, Fasching PA, Haeberle L, Ekici AB, Beckmann MW, Gibson L, Aitken Z, et al.
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  66. Selective modulation of the functions of a conserved DNA motor by a histone fold complex.
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  67. Human nuclear ARGONAUTE 2 interacts in vivo only with small RNAs and not with DNA.
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  68. Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion.
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  69. Prohibitin: A Novel Molecular Player in KDEL Receptor Signalling.
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  70. Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway.
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  71. Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration.
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  72. No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.
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  73. Emergence of Multiple EGFR Extracellular Mutations during Cetuximab Treatment in Colorectal Cancer.
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  74. The Mps1 kinase modulates the recruitment and activity of Cnn1(CENP-T) at Saccharomyces cerevisiae kinetochores.
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  75. New insights in the control of vascular permeability: vascular endothelial-cadherin and other players.
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  76. The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
    Medico E, Russo M, Picco G, Cancelliere C, Valtorta E, Corti G, Buscarino M, Isella C, Lamba S, Martinoglio B, Veronese S, Siena S, Sartore-Bianchi A, Beccuti M, Mottolese M, Linnebacher M, Cordero F, Di Nicolantonio F, Bardelli A.
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  77. Replication and transcription on a collision course: eukaryotic regulation mechanisms and implications for DNA stability.
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  78. An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers.
    Blein S, Bardel C, Danjean V, McGuffog L, Healey S, Barrowdale D, Lee A, Dennis J, Kuchenbaecker KB, Soucy P, Terry MB, Chung WK, Goldgar DE, Buys SS; Breast Cancer Family Registry, Janavicius R, Tihomirova L, Tung N, Dorfling CM, van Rensburg EJ, Neuhausen SL, Ding YC, et al.
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  79. XomAnnotate: Analysis of Heterogeneous and Complex Exome- A Step towards Translational Medicine.
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  80. Common germline polymorphisms associated with breast cancer-specific survival.
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  81. Oxidative Stress during the Progression of Β-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer's Disease.
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  82. ChIP-Seq and RNA-Seq analyses identify components of the Wnt and Fgf signaling pathways as Prep1 target genes in mouse embryonic stem cells.
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  83. Purification and characterization of a DNA-binding recombinant PREP1:PBX1 complex.
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  84. Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.
    Rebbeck TR, Mitra N, Wan F, Sinilnikova OM, Healey S, !McGuffog L, Mazoyer S, Chenevix-Trench G, Easton DF, Antoniou AC, Nathanson KL; CIMBA Consortium, Laitman Y, Kushnir A, Paluch-Shimon S, Berger R, Zidan J, Friedman E, Ehrencrona H, Stenmark-Askmalm M, Einbeigi Z, Loman N, et al.
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  85. Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers.
    Blanco I, Kuchenbaecker K, Cuadras D, Wang X, Barrowdale D, de Garibay GR, Librado P, Sánchez-Gracia A, Rozas J, Bonifaci N, McGuffog L, Pankratz VS, Islam A, Mateo F, Berenguer A, Petit A, Català I, Brunet J, Feliubadaló L, Tornero E, Benítez J, Osorio A, et al.
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  86. SEPN1, an endoplasmic reticulum-localized selenoprotein linked to skeletal muscle pathology, counteracts hyperoxidation by means of redox-regulating SERCA2 pump activity.
    Marino M, Stoilova T, Giorgi C, Bachi A, Cattaneo A, Auricchio A, Pinton P, Zito E.
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  87. Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
    Michailidou K, Beesley J, Lindstrom S, Canisius S, Dennis J, Lush MJ, Maranian MJ, Bolla MK, Wang Q, Shah M, Perkins BJ, Czene K, Eriksson M, Darabi H, Brand JS, Bojesen SE, Nordestgaard BG, Flyger H, Nielsen SF, Rahman N, Turnbull C; BOCS, et al.
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  88. Whole exome sequencing identifies driver mutations in asymptomatic computed tomography-detected lung cancers with normal karyotype.
    Belloni E, Veronesi G, Rotta L, Volorio S, Sardella D, Bernard L, Pece S, Di Fiore PP, Fumagalli C, Barberis M, Spaggiari L, Pelicci PG, Riva L.
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  89. Transgenic fatal familial insomnia mice indicate prion infectivity-independent mechanisms of pathogenesis and phenotypic expression of disease.
    Bouybayoune I, Mantovani S, Del Gallo F, Bertani I, Restelli E, Comerio L, Tapella L, Baracchi F, Fernàndez-Borges N, Mangieri M, Bisighini C, Beznoussenko GV, Paladini A, Balducci C, Micotti E, Forloni G, Castilla J, Fiordaliso F, Tagliavini F, Imeri L, Chiesa R.
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  90. Nuclear envelope and chromatin, lock and key of genome integrity.
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  91. miR-Test: a blood test for lung cancer early detection.
    Montani F, Marzi MJ, Dezi F, Dama E, Carletti RM, Bonizzi G, Bertolotti R, Bellomi M, Rampinelli C, Maisonneuve P, Spaggiari L, Veronesi G, Nicassio F, Di Fiore PP, Bianchi F
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  92. p63 Sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling.
    Memmi EM, Sanarico AG, Giacobbe A, Peschiaroli A, Frezza V, Cicalese A, Pisati F, Tosoni D, Zhou H, Tonon G, Antonov A, Melino G, Pelicci PG, Bernassola F.
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  93. Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells
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  94. A functional in vitro model of heterotypic interactions reveals a role for interferon-positive carcinoma associated fibroblasts in breast cancer.
    Hosein AN, Livingstone J, Buchanan M, Reid JF, Hallett M, Basik M.
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  95. Concerted and differential actions of two enzymatic domains underlie Rad5 contributions to DNA damage tolerance.
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  96. Trans-membrane area asymmetry controls the shape of cellular organelles.
    Beznoussenko GV, Pilyugin SS, Geerts WJ, Kozlov MM, Burger KN, Luini A, Derganc J, Mironov AA.
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  97. PW1/Peg3 expression regulates key properties that determine mesoangioblast stem cell competence.
    Bonfanti C, Rossi G, Tedesco FS, Giannotta M, Benedetti S, Tonlorenzi R, Antonini S, Marazzi G, Dejana E, Sassoon D, Cossu G, Messina G.
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  98. Error-free DNA damage tolerance and sister chromatid proximity during DNA replication rely on the Polα/Primase/Ctf4 Complex.
    Fumasoni M, Zwicky K, Vanoli F, Lopes M, Branzei D.
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  99. Mast Cells Are Required for Full Expression of Allergen/SEB-Induced Skin Inflammation.
    Ando T, Matsumoto K, Namiranian S, Yamashita H, Glatthorn H, Kimura M, Dolan BR, Lee JJ, Galli SJ, Kawakami Y, Jamora C, Kawakami T.
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  100. An epigenetic view of B-cell disorders.
    Alberghini F, Petrocelli V, Rahmat M, Casola S.
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  101. The role of non-coding RNAs in the regulation of stem cells and progenitors in the normal mammary gland and in breast tumors
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  102. Epithelial-to-Mesenchymal Plasticity Harnesses Endocytic Circuitries.
    Corallino S, Malabarba MG, Zobel M, Di Fiore PP, Scita G.
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  103. Nuclear and cellular plasticity: nuclear RAC1 takes center stage.
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  104. A targeted approach to genetic counseling in breast cancer patients: the experience of an Italian local project
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  105. Antibody repertoire diversification through VH gene replacement in mice cloned from an IgA plasma cell
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  106. Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer.
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  107. Mining cancer gene expression databases for latent information on intronic microRNAs
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  108. Higher metastatic efficiency of KRas G12V than KRas G13D in a colorectal cancer model.
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  109. Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
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  110. USP9X Controls EGFR Fate by Deubiquitinating the Endocytic Adaptor Eps15
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  111. The hidden genomic landscape of acute myeloid leukemia: subclonal structure revealed by undetected mutations
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  112. Collective cell motility promotes chemotactic prowess and resistance to chemorepulsion.
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  113. The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/Β-catenin signaling.
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  114. A protein restriction-dependent sulfur code for longevity.
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  115. A monoclonal antibody specific for prophase phosphorylation of histone deacetylase 1: a readout for early mitotic cells.
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  117. Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk.
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  118. Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.
    Peterlongo P, Chang-Claude J, Moysich KB, Rudolph A, Schmutzler RK, Simard J, Soucy P, Eeles RA, Easton DF, Hamann U, Wilkening S, Chen B, Rookus MA, Schmidt MK, van der Baan FH, Spurdle AB, Walker LC, Lose F, Maia AT, Montagna M, Matricardi L, Lubinski J, et al.
    Cancer Epidemiol Biomarkers Prev. 2015 Jan;24(1):308-16. doi: 10.1158/1055-9965.EPI-14-0532. Epub 2014 Oct 21.
    [PMID: 25336561] IF 4,125

  119. Correlative video-light-electron microscopy of mobile organelles.
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    [PMID: 25702127] IF 4,125

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