Fabrizio d'Adda di Fagagna Lab

Fabrizio d'Adda di Fagagna

Fabrizio d'Adda di Fagagna, Ph.D. is a cell and molecular biologist that studies the involvement of the DNA damage response (DDR) pathways in physiologically-relevant processes such as aging and cancer.
Fabrizio studied Biology at the University of Trieste and obtained his Ph.D. in Molecular Genetics at SISSA, the International School for Advanced Studies, in Trieste, Italy, while working at ICGEB (International Centre for Genetic Engineering and Biotechnology) under the guidance of Mauro Giacca and Arturo Falaschi. read more

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DNA Damage Response and Cellular Senescence

We study the physiological consequences of DNA damage at the cellular and organismal level mainly in mammals. Nuclear DNA damage triggers a signaling and effector pathway known as the DNA damage response (DDR) that coordinates cell-cycle arrest (checkpoint functions) and DNA repair. read more about the program

Laboratory location: Milan, Italy

Recent publications

Mikolaj Ogrodnik, Juan Carlos Acosta, Peter D Adams, Fabrizio d'Adda di Fagagna, Darren J Baker, Cleo L Bishop, Tamir Chandra, Manuel Collado, Jesus Gil, Vassilis Gorgoulis, Florian Gruber, Eiji Hara, Pidder Jansen-Dürr, Diana Jurk, Sundeep Khosla, James L Kirkland, Valery Krizhanovsky, Tohru Minamino, Laura J Niedernhofer, João F Passos , Nadja A R Ring, Heinz Redl, Paul D Robbins, Francis Rodier, Karin Scharffetter-Kochanek, John M Sedivy, Ewa Sikora, Kenneth Witwer, Thomas von Zglinicki, Maximina H Yun, Johannes Grillari, Marco Demaria
Guidelines for minimal information on cellular senescence experimentation in vivo
Cell. 2024 Aug 8;187(16):4150-4175. doi: 10.1016/j.cell.2024.05.059.

Fabrizio d’Adda di Fagagna
In memoriam Judy Campisi: spreading cellular senescence
Nat Rev Mol Cell Biol. 2024 Apr 12. doi: 10.1038/s41580-024-00736-w. Online ahead of print.

Christopher D. Wiley, Eiji Hara & Fabrizio d’Adda di Fagagna
Judith Campisi (1948–2024)
Nature Aging (2024)

Ilaria Rosso, Corey Jones-Weinert, Francesca Rossiello, Matteo Cabrini, Silvia Brambillasca, Leonel Munoz-Sagredo, Zeno Lavagnino, Emanuele Martini, Enzo Tedone, Massimiliano Garre’, Julio Aguado, Dario Parazzoli, Marina Mione, Jerry W. Shay, Ciro Mercurio & Fabrizio d’Adda di Fagagna
Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs
Nat Commun. 2023 Nov 4;14(1):7086. doi: 10.1038/s41467-023-42831-0.

Ubaldo Gioia, Sara Tavella, Pamela Martínez-Orellana, Giada Cicio, Andrea Colliva, Marta Ceccon, Matteo Cabrini, Ana C Henriques, Valeria Fumagalli, Alessia Paldino, Ettore Presot, Sreejith Rajasekharan, Nicola Iacomino, Federica Pisati, Valentina Matti, Sara Sepe, Matilde Conte, Sara Barozz, Zeno Lavagnino, Tea Carletti, Maria Concetta Volpe, Paola Cavalcante, Matteo Iannacone, Chiara Rampazzo, Rossana Bussani, Claudio Tripodo, Serena Zacchigna, Alessandro Marcello, Fabrizio d'Adda di Fagagna
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
Nat Cell Biol. 2023 Mar 9. doi: 10.1038/s41556-023-01096-x. Online ahead of print.

complete list PubMed Google Scholar F1000

Group members

Staff Scientist

Rossiello Francesca
Sepe Sara

Post Doc

Cabrini Matteo
Falcinelli Marta
Mancheno Ferris Alexandra
Oppezzo Alessia
Rey Federica
Simoni Matilde
Tavella Sara

PhD Student

Terraneo Federica
Trastus Lucrezia

Guest researcher

Eugenia Marinelli

Research Tecnichian Fellow

Cicio Giada Lucia

Former members

Oscar Sapkota
Marta Ceccon
Okita Akiko
Alessia Di Lillo
Ilaria Rosso
Anna De Polo (Postdoc at Italian Institute of Technology - IIT, Milan, Italy)
Matilde Conte
Giulia Dell’Omo (Roche)
Valentina Matti
Corey Jones-Weinert (Postdoctoral fellow at Salk Institute for Biological Studies, California)
Sofia Francia (Resarcher at IGM-CNR, Pavia)
Ubaldo Gioia (Resarcher at IGM-CNR, Pavia)
Sara Boggio
Do Espirito Santo Henriques Ana Cristina
Flavia Michelini (Associate Director Astrazeneca)
Marek Adamowicz (Postdoc at University of Sussex, Brighton, UK)
Julio Aguado (Postdoc at the Australian Institute for Bioengineering
and Nanotechnology,
University of Queensland - Brisbane, Australia)
Aurora Cerutti (Senior Scientist at Artios Pharma, Cambridge UK)
Giuseppina D'Alessandro (Postdoc at the University of Cambridge)
Raffaella Di Micco (Principal Investigator at San Raffaele Telethon Institute for Gene Therapy)
Miriana Dobreva (Sanofi)
Matteo Formenti (Technician at Ludwig Institute for Cancer Research, Brussels, Belgium)
Marzia Fumagalli (Head of Technology Transfer Office at IEO)
Alessandro Galbiati (Senior Scientist II - Team Leader Cell based assay development and screening at Artios)
Fabio Iannelli (Bioinformatician at IFOM)
Muege Ogrunc (CSO at Stark Labs)
Fabio Pessina (Senior Research Technician at Human Technopole)
Leonid Schneider
Marie Sgandurra (Lab scientist, Université de Lausanne, CH)
Sheetal Sharma (Assistant Professor, Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Sciences, Chandigarh, India )
Lucia Spath (Italian Coast Guard Officer)
Gabriele Sulli (Assistant Professor, Scintillon Institute, San Diego California)
Jelena Vermezovic (Postdoc in IFOM)
Valerio Vitelli

(update: Aug 2024)