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Marta Kovatcheva Lab

Marta Kovatcheva

Marta was born in Sofia, Bulgaria and grew up in Toronto, Canada. She obtained her Hon. BSc. in Molecular Genetics at the University of Toronto in 2010. Marta completed her undergraduate thesis under the supervision of Dr. Daniel Durocher, studying the role of ubiquitin signaling in the double strand break DNA damage response. read more

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Cell Plasticity & Aging

The concept of “cell plasticity” refers to the capacity of a cell to adopt different identities without any genetic mutations. A classic example of cell plasticity occurs during development, when embryonic stem cells differentiate into the immense diversity of cell types we see in the adult body. It is now appreciated that cell plasticity also plays an important role in adult tissues, particularly in the context of injury and regeneration, where it is indispensable for tissue repair. read more

Laboratory location: Milan, Italy

Recent publications

  1. Marta Kovatcheva, Elena Melendez, Dafni Chondronasiou, Federico Pietrocola, Raquel Bernad, Adrià Caballe, Alexandra Junza, Jordi Capellades, Adrián Holguín-Horcajo, Neus Prats, Sylvere Durand, Meritxell Rovira, Oscar Yanes, Camille Stephan-Otto Attolini, Guido Kroemer, Manuel Serrano
    Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair
    Nat Metab. 2023 Nov;5(11):1911-1930. doi: 10.1038/s42255-023-00916-6. Epub 2023 Nov 16.
  2. Inés Domínguez-López, Marta Kovatcheva, Rosa Casas, Estefanía Toledo, Montserrat Fitó, Emilio Ros, Ramon Estruch, Manuel Serrano 4 9, Rosa M Lamuela-Raventós
    Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice
    J Sci Food Agric. 2024 Jan 30;104(2):875-882. doi: 10.1002/jsfa.12976. Epub 2023 Sep 19.
  3. Mary E Klein, Marta Kovatcheva, Lara E Davis, William D Tap, Andrew Koff
    CDK4/6 Inhibitors: The Mechanism of Action May Not Be as Simple as Once Thought
    Cancer Cell. 2018 Jul 9;34(1):9-20. doi: 10.1016/j.ccell.2018.03.023. Epub 2018 May 3.
  4. Marta Kovatcheva, Will Liao, Mary E Klein, Nicolas Robine, Heather Geiger, Aimee M Crago, Mark A Dickson, William D Tap, Samuel Singer, Andrew Koff
    ATRX is a regulator of therapy induced senescence in human cells
    Nat Commun. 2017 Aug 30;8(1):386. doi: 10.1038/s41467-017-00540-5.
  5. Marta Kovatcheva, David D Liu, Mark A Dickson, Mary E Klein, Rachael O'Connor, Fatima O Wilder, Nicholas D Socci, William D Tap, Gary K Schwartz, Samuel Singer, Aimee M Crago, Andrew Koff
    MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition
    Oncotarget. 2015 Apr 10;6(10):8226-43. doi: 10.18632/oncotarget.3364.
selected list PubMed

Group members

Post doc
Christina Fissoun
Phd Student
Saket Bhargava
Temporary Fellowship
Benedetta Mannelli

(update: Sep 2024)