Vincenzo Costanzo Lab

Recent publications

• RAD51 protects abasic sites to prevent replication fork breakage.
  Hanthi YW, Ramirez-Otero MA, Appleby R, De Antoni A, Joudeh L, Sannino V, Waked S, Ardizzoia A, Barra V, Fachinetti D, Pellegrini L, Costanzo V.
  Mol Cell. 2024 Aug 22;84(16):3026-3043.e11.
  doi: 10.1016/j.molcel.2024.07.004
• POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps.
  Mann A, Ramirez-Otero MA, De Antoni A, Hanthi YW, Sannino V, Baldi G, Falbo L, Schrempf A, Bernardo S, Loizou J, Costanzo V.
  Mol Cell. 2022 Nov 17;82(22):4218-4231.e8.
  doi: 10.1016/j.molcel.2022.09.013
• REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps.
  Taglialatela A, Leuzzi G, Sannino V, Cuella-Martin R, Huang JW, Wu-Baer F, Baer R, Costanzo V, Ciccia A.
  Mol Cell. 2021 Oct 7;81(19):4008-4025.e7.
  doi: 10.1016/j.molcel.2021.08.016.
• SSRP1-mediated histone H1 eviction promotes replication origin assembly and accelerated development.
  Falbo L, Raspelli E, Romeo F, Fiorani S, Pezzimenti F, Casagrande F, Costa I, Parazzoli D, Costanzo V.
  Nat Commun. 2020 Mar 12;11(1):1345.
  doi: 10.1038/s41467-020-15180-5
• ATR expands embryonic stem cell fate potential in response to replication stress.
  Atashpaz S, Samadi Shams S, Gonzalez JM, Sebestyén E, Arghavanifard N, Gnocchi A, Albers E, Minardi S, Faga G, Soffientini P, Allievi E, Cancila V, Bachi A, Fernández-Capetillo Ó, Tripodo C, Ferrari F, López-Contreras AJ, Costanzo V.
  Elife. 2020 Mar 12;9:e54756.
  doi: 10.7554/eLife.54756