IFOM Vincenzo Costanzo Lab

Vincenzo Costanzo Lab

Vincenzo Costanzo

Italian, born in Naples in '73, Vincenzo Costanzo directs the DNA Metabolism research program at IFOM.
In 1998, he graduated in Medicine and Surgery at the University of Naples Federico II. His college years were crucial for laying the foundations of his scientific career. read more

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DNA Metabolism

Cells respond to DNA damage and replication stress, by activating a multi-faceted response called DNA damage response. In contrast to lower eukaryotes many genes involved in DNA repair and in DNA damage response are lethal when inactivated in mammalian cells even in the absence of apparent DNA damage.read more

Laboratory location: Milan, Italy

Recent publications

  • Kolinjivadi AM, Sannino V, De Antoni A, Zadorozhny K, Kilkenny M, Técher H, Baldi G, Shen R, Ciccia A, Pellegrini L, Krejci L and Costanzo V.
    Smarcal1-mediated fork reversal triggers Mre11-dependent degradation of nascent DNA in the absence of Brca2 and stable Rad51 nucleofilaments.
    Mol Cell. 2017 Sep 7;67(5):867-881.e7. doi: 10.1016/j.molcel.2017.07.001. Epub 2017 Jul 27.
  • Angelo Taglialatela, Silvia Alvarez Nanez, Giuseppe Leuzzi, Vincenzo Sannino, Lepakshi Ranjha, Jen-Wei Huang, Chioma Madubata, Brynn Levy, Raul Rabadan, Petr Cejka, Vincenzo Costanzo and Alberto Ciccia.
    Restoration of replication fork stability and genome integrity in BRCA1- and BRCA2-deficient cells by inactivation of SNF2-family fork remodelers
    Mol Cell. 2017 Oct 19;70(5)
  • Zadorozhny K, Sannino V, Beláň O, Mlčoušková J, Špírek M, Costanzo V*, Krejčí L*.
    Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection.
    Cell Rep. 2017 Oct 10;21(2):333-340. doi: 10.1016/j.celrep.2017.09.062
    (*Corresponding authors)

Group members

Sina Atashpazgargari
Swagata Hadler
Hervé Techer
Sara Samadi
Anna De Antoni
Lucia Falbo
Federica Pezzimenti
Erica Raspelli
Francesco Romeo
Vincenzo Sannino
Maria Vinciguerra
PhD students
Giorgio Baldi
Andrea Gnocchi
Anjali Mann
Negar Arghavanifard

update: October 2017

In the press

Nobel Chimica: esperti, da studi nuovo approccio contro il cancro
AGI

2015.10.08 

La Molecola che si ripara da sola
Radio3Scienza

2015.10.08  | URL

Il Nobel ai meccanici del DNA
Il Messaggero

2015.10.08 | Carla Massi

L'origine della Microcefalia
Italiasalute

2015.07.22

Microcefalia: ecco la proteina che regola lo sviluppo del cervello
Adnkronos

2015.07.21

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