Claudio Tripodo Lab

Claudio Tripodo

Claudio Tripodo, born in Palermo in 1978, is a pathologist specializing in tumor immunology, with a strong focus on studying the tumor microenvironment. He graduated in Medicine and Surgery in 2002 from the University of Palermo with top honors, including summa cum laude and a commendation for his experimental thesis. During his university years, he developed a passion for immunopathology, attending the Immunology Unit at the same university. After graduation, he continued his training, completing his specialization in Pathology in 2007, again with honors.
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Advanced Pathology Laboratory

The Advanced Pathology Lab IFOM, under the leadership of Professor Claudio Tripodo, is dedicated to advancing the understanding of tumor biology, with a particular emphasis on the mechanisms that drive tumor heterogeneity and the role of stromal tissue remodeling in cancer progression. The lab adopts a multidisciplinary approach that integrates quantitative and molecular pathology, immunology, and cellular biology, focusing on the spatial and temporal dynamics of tumors within their native microenvironments.
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Laboratory location: Milan, Italy

Recent Publications

Martin S, Scorzoni S, Cordone S, Mazzagatti A, Beznoussenko GV, Gunn AL, Di Bona M, Eliezer Y, Leor G, Ben-Yishay T, Loffreda A, Cancila V, Rainone MC, Ippolito MR, Martis V, Bedin F, Garrè M, Vaites LP, Vasapolli P, Polo S, Parazzoli D, Tripodo C, Mironov AA, Cuomo A, Ben-David U, Bakhoum SF, Hatch EM, Ly P, Santaguida S.
A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements.
Science. 2024 Aug 30;385(6712):eadj7446. doi: 10.1126/science.adj7446. Epub 2024 Aug 30. PMID: 39208097.

Gambardella AR, Antonucci C, Zanetti C, Noto F, Andreone S, Vacca D, Pellerito V, Sicignano C, Parrottino G, Tirelli V, Tinari A, Falchi M, De Ninno A, Businaro L, Loffredo S, Varricchi G, Tripodo C, Afferni C, Parolini I, Mattei F, Schiavoni G.
IL-33 stimulates the anticancer activities of eosinophils through extracellular vesicle-driven reprogramming of tumor cells.
J Exp Clin Cancer Res. 2024 Jul 27;43(1):209. doi: 10.1186/s13046-024-03129-1. PMID: 39061080; PMCID: PMC11282757.

Zhang X, Venkatachalapathy S, Paysan D, Schaerer P, Tripodo C, Uhler C, Shivashankar GV.
Unsupervised representation learning of chromatin images identifies changes in cell state and tissue organization in DCIS.
Nat Commun. 2024 Jul 20;15(1):6112. doi: 10.1038/s41467-024-50285-1. PMID: 39030176; PMCID: PMC11271523.

complete list

Group members

Staff Scientist

Blazevits Olga

Post Doc

Ripa Silvia

Physician Scientist

Frigo Emanuele

Phd Student SEMM

Emanuele Savino

Technician

Cicio Giada Lucia

Undergraduate Student

Ghiselli Ricci Alice

(update: Jan 2026)