Giannino Del Sal Lab

Giannino Del Sal

Giannino Del Sal studied biology at the University of Trieste and had his research training at the International Centre for Genetic Engineering and Biotechnology (ICGEB) in Trieste (Italy), at the European Molecular Biology Laboratory (EMBL) in Heidelberg (Germany) working with Claudio Schneider, and at LNCIB in Trieste where since 1996 he has been Head of the Molecular Oncology Unit.

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Signalling, tumor environment and cell metabolism

This research program stems from the long lasting experience of Giannino Del Sal in the field of cancer biology, particularly in the study of the wild-type p53/mutant p53 molecular networks, and from several breakthrough discoveries he made on these pathways. p53 is a tumour suppressor and it regulates almost every facet of cell behaviour.

Laboratory location: Trieste, Italy

Last publications

Bertolio R, Napoletano F, Del Sal G (2023)
Dynamic links between mechanical forces and metabolism shape the tumor milieu.
CURR OPIN CELL BIOL 2023 Oct; 84: 102218 doi.org/10.1016/j.ceb.2023.102218

Camilla Tombari,Alessandro Zannini,Rebecca Bertolio,Silvia Pedretti,Matteo Audano,Luca Triboli, Valeria Cancila,Davide Vacca,Manuel Caputo,Sara Donzelli, Ilaria Segatto, Simone Vodret, Silvano Piazza, Alessandra Rustighi,Fiamma Mantovani,Barbara Belletti, Gustavo Baldassarre,Giovanni Blandino, Claudio Tripodo, Silvio Bicciato,Nico Mitro,Giannino Del Sal
Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth
Nat Commun. 2023 Oct 25;14(1):6777. doi: 10.1038/s41467-023-42458-1.

Napoletano, F., Ferrari Bravo, G., Voto, I.A.P., Santin, S., Celora, L., Campaner, E., Dezi, C., Bertossi, A., Valentino, E., Santorsola, M., Rustighi, A., Fajner, V., Maspero, E., Ansaloni, F., Cancila, V., Valenti, C.F., Santo, M., Artimagnella, O.B., Finaurini, S., Gioia, U., Polo, S., Sanges, R., Tripodo, C., Mallamaci, A., Gustincich, S., d’Adda di Fagagna, F., Mantovani, F., Specchia, V., Del Sal, G. (2021).
The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.
Cell Reports 36, 109694.

Valeria Capaci, Lorenzo Bascetta, Marco Fantuz, Galina V Beznoussenko, Roberta Sommaggio, Valeria Cancila, Andrea Bisso, Elena Campaner, Alexander A Mironov, Jacek R Wiśniewski, Luisa Ulloa Severino, Denis Scaini, Fleur Bossi, Jodi Lees, Noa Alon, Ledia Brunga, David Malkin, Silvano Piazza, Licio Collavin, Antonio Rosato, Silvio Bicciato, Claudio Tripodo, Fiamma Mantovani, Giannino Del Sal
Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome
Nat Commun. 2020 Aug 7;11(1):3945. doi: 10.1038/s41467-020-17596-5.