IFOM Stefano Casola Lab

Stefano Casola Lab

Stefano Casola

Molecular oncologist and expert in the study of B-lymphocytes and lymphomas, Stefano Casola directs the unit of Genetics of B cells and lymphomas at IFOM.
At age 24, Casola graduated from the Faculty of Medicine at the University Federico II of Naples. He had one goal in mind: understanding cancer. This drive led him in 1997 to the Institute of Genetics, University of Cologne, Germany where he worked at the forefront under the mentorship of prominent immunologist Klaus Rajewsky. read more

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Genetics of B Cells and Lymphomas

The pool of peripheral B lymphocytes is established through an ordered set of molecular events initiated in the bone marrow with the assembly on the surface of the cells of a functional, non-autoimmune, B cell antigen receptor (BCR) complex. Expression and signaling through the BCR is essential for developing B cells to differentiate respectively into follicular, marginal zone or B-1 B cells, each of these subsets displaying a specific effector function. read more

Laboratory location: Milan, Italy

Recent publications

  • Mihailovich M, Bremang M, Spadotto V, Musiani D, Vitale E, Varano G, Zambelli F, Mancuso FM, Cairns DA, Pavesi G, Casola S, Bonaldi T.
    miR-17-92 fine-tunes MYC expression and function to ensure optimal B cell lymphoma growth.
    Nat Commun. 2015 Nov 10;6:8725. doi: 10.1038/ncomms9725. PubMed PMID: 26555894.
  • Kumar R, Bach MP, Mainoldi F, Maruya M, Kishigami S, Jumaa H, Wakayama T, Kanagawa O, Fagarasan S, Casola S.
    Antibody repertoire diversification through VH gene replacement in mice cloned from an IgA plasma cell.
    Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E450-7. doi: 10.1073/pnas.1417988112. Epub 2015 Jan 21. PubMed PMID: 25609671.
  • Alberghini F, Petrocelli V, Rahmat M, Casola S.
    An epigenetic view of B-cell disorders.
    Immunol Cell Biol. 2015 Mar;93(3):253-60. doi: 10.1038/icb.2014.116. Epub 2015 Jan 20. Review. PubMed PMID: 25601271.

Group members

Post-doctoral fellow
Valentina Petrocelli
Laura Perucho
Bioinformatician
Federica Zanardi
PhD student
Martina Sormani
Research fellow
Elisabetta Di Simone
Research assistant
Federica Mainoldi

(updated: Jan 2016)

IFOM Review

Lymphomas: the backstage of the research that highlights their complexity and recommends the use of combined therapies
Commentary on Varano et al. "The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition", Nature 2017, 546:302-6. by Klaus Rajewsky
Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis
Commentary on Stefano Casola's paper published onThe Journal of Clinical Investigation, by Riccardo Dalla-Favera (2014)
Cell Reprogramming Requires Silencing of a Core Subset of Polycomb Targets
Commentary on Stefano Casola's paper published on PLoS genetics, by Gustavo Mostoslavsky (2014)
complete review

In the press

Come provare a far tornare i cervelli in fuga
Wired

2014.11.10 | Sandro Iannaccone

Animali e Medicina. Un topo ci salverà
L'Eco di Bergamo

2014.10.13

L'incontro di BergamoScienza
Il Corriere della Sera - Ed. Bergamo

2014.10.11

La Provincia
Tutti invitati alla festa della scienza

2014.10.02 | Marco Cambiaghi

Tutti invitati alla festa della scienza
La Provincia

2014.10.02 | Marco Cambiaghi

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