Stefano Piccolo Lab
Stefano Piccolo
Stefano Piccolo was born in 1967, in Italy. He obtained his MSc in Biology (1991) and his Ph.D (1995) from the University of Padua, where he worked under Giorgio Bressan on the regulation and function of the extracellular matrix proteins.
Tissue biology and tumorigenesis
In living organs, cells are in intimate contact with each other and with their microenvironment. Within tissues, cells display remarkable, and yet mysterious, “social” behaviors. Prominent examples are the ability of cells to stop proliferating (i.e., of making copies of themselves) when they start touching each other; to change their destiny to accommodate tissue needs; or to self-organize into new tissue during the repair of damaged organs. Healthy tissues can also recognize individual tumor cells and either eliminate them or "normalize" their behavior, as such taming the effect of oncogenic mutations.
read moreLast publications
- Piccolo S, Panciera T, Contessotto P, Cordenonsi M.
YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches.
Nat Cancer Jan;4(1):9-26. doi: 10.1038/s43018-022-00473-z. - Sladitschek-Martens HL, Guarnieri A, Brumana G, Zanconato F, Battilana G, Xiccato RL, Panciera T, Forcato M, Bicciato S, Guzzardo V, Fassan M, Ulliana L, Gandin A, Tripodo C, Foiani M, Brusatin G, Cordenonsi M, Piccolo S
YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING.
Nature Jul;607(7920):790-798. doi: 10.1038/s41586-022-04924-6. - Piccolo S, Sladitschek-Martens HL, Cordenonsi M.
Mechanosignaling in vertebrate development.
Dev Biol.Aug;488:54-67. doi: 10.1016/j.ydbio.2022.05.005. - Battilana, G., Zanconato, F., and Piccolo, S. (2021).
Mechanisms of YAP/TAZ transcriptional control.
Cell Stress 5, 167-172. 10.15698/cst2021.11.258. - Castellan, M., Guarnieri, A., Fujimura, A., Zanconato, F., Battilana, G., Panciera, T., Sladitschek, H.L., Contessotto, P., Citron, A., Grilli, A., Romano O, Bicciato S, Fassan M, Porcù E, Rosato A, Cordenonsi M and Piccolo S. (2021)
Single-cell analyses reveal YAP/TAZ as regulators of stemness and cell plasticity in Glioblastoma.
Nat Cancer 2, 174-188. 10.1038/s43018-020-00150-z. - Rajewsky, N., Almouzni, G., Gorski, S.A., Aerts, S., Amit, I., Bertero, M.G., Bock, C., Bredenoord, A.L., Cavalli, G., Chiocca, S., Piccolo S., et al. (2020).
LifeTime and improving European healthcare through cell-based interceptive medicine.
Nature 587, 377-386. 10.1038/s41586-020-2715-9. - Panciera T, Citron A, Di Biagio D, Battilana G, Gandin A, Giulitti S, Forcato M, Bicciato S, Panzetta V, Fusco S, Azzolin L, Totaro A, Dei Tos AP, Fassan M, Vindigni V, Bassetto F, Rosato A, Brusatin G, Cordenonsi M, Piccolo S.
Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties.
Nat Mater. 2020 Feb 17. doi: 10.1038/s41563-020-0615-x.
Group members
Francesca ZanconatoTito Panciera
Luca Azzolin
Michelangelo Cordenonsi
(update: May 2018)