Advanced Light Microscopy
Mattia Pavani
Technician
Mattia Pavani graduated in Molecular Biology of the Cell from the University of Milan in 2017. He obtained his PhD in 2022 from the University of Galway under the supervision of Dr. Andrea Ciliberto, working in the Quantitative Biology of Cell Division laboratory at IFOM. His doctoral research focused on understanding mechanisms of resistance and tolerance in eukaryotic cells to microtubule-targeting agents that induce microtubule depolymerization. In 2023, Mattia joined the Metabolic Reprogramming in Solid Tumors laboratory led by Dr. Claudio Vernieri at IFOM as a postdoctoral researcher, where he investigated strategies to improve the efficacy of microtubule poisons by modulating cancer metabolism, using models of Triple-Negative Breast Cancer. Throughout his career, he has developed extensive expertise in imaging techniques applied to both yeast and mammalian cell lines, fostering a strong interest in microscopy. Since 2025, he has been a member of the IFOM Advanced Light Microscopy facility, applying advanced imaging technologies to support cancer research.
- Epistasis, aneuploidy, and functional mutations underlie evolution of resistance to induced microtubule depolymerization. Pavani M, Bonaiuti P, Chiroli E, Gross F, Natali F, Macaluso F, Póti Á, Pasqualato S, Farkas Z, Pompei S, Cosentino Lagomarsino M, Rancati G, Szüts D, Ciliberto A. EMBO J. 2021 Nov 15;40(22):e108225. doi: 10.15252/embj.2021108225. Epub 2021 Oct 4. PMID: 34605051; PMCID: PMC8591535.
- Triap1 upregulation promotes escape from mitotic-slippage-induced G1 arrest. Pavani M, Chiroli E, Cancrini C, Gross F, Bonaiuti P, Villa S, Giavazzi F, Matafora V, Bachi A, Fava LL, Lischetti T, Ciliberto A. Cell Rep. 2023 Mar 28;42(3):112215. doi: 10.1016/j.celrep.2023.112215. Epub 2023 Mar 13. PMID: 36917609.
- Mechanical stress during confined migration causes aberrant mitoses and c-MYC amplification. Bastianello G, Kidiyoor GR, Lowndes C, Li Q, Bonnal R, Godwin J, Iannelli F, Drufuca L, Bason R, Orsenigo F, Parazzoli D, Pavani M, Cancila V, Piccolo S, Scita G, Ciliberto A, Tripodo C, Pagani M, Foiani M. Proc Natl Acad Sci U S A. 2024 Jul 16;121(29):e2404551121. doi: 10.1073/pnas.2404551121. Epub 2024 Jul 11. PMID: 38990945; PMCID: PMC11260125.
