Publications Vincenzo Costanzo

  1. Zhao Z, Oh S, Li D, Ni D, Pirooz SD, Lee JH, Yang S, Lee JY, Ghozalli I, Costanzo V, Stark JM, Liang C.
    A Dual Role for UVRAG in Maintaining Chromosomal Stability Independent of Autophagy.
    Dev Cell. 2012 May 15;22(5):1001-16. Epub 2012 Apr 26.

  2. Ray Chaudhuri A, Hashimoto Y, Herrador R, Neelsen KJ, Fachinetti D, Bermejo R, Cocito A, Costanzo V, Lopes M.
    Topoisomerase I poisoning results in PARP-mediated replication fork reversal.
    Nat Struct Mol Biol. 2012 Mar 4;19(4):417-23. doi: 10.1038/nsmb.2258.

  3. Errico A, Costanzo V.
    Mechanisms of replication fork protection: a safeguard for genome stability.
    Crit Rev Biochem Mol Biol. 2012 May;47(3):222-35. Epub 2012 Feb 11.

  4. Lazzaro F, Novarina D, Amara F, Watt DL, Stone JE, Costanzo V, Burgers PM, Kunkel TA, Plevani P, Muzi-Falconi M.
    RNase H and postreplication repair protect cells from ribonucleotides incorporated in DNA.
    Mol Cell. 2012 Jan 13;45(1):99-110.

  5. Hashimoto Y, Puddu F, Costanzo V.
    RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks.
    Nat Struct Mol Biol. 2011 Dec 4;19(1):17-24. doi: 10.1038/nsmb.2177.

  6. Costanzo V.
    Brca2, Rad51 and Mre11: performing balancing acts on replication forks.
    DNA Repair (Amst). 2011 Oct 10;10(10):1060-5. Epub 2011 Sep 6. Review.

  7. Hashimoto Y, Costanzo V.
    Studying DNA replication fork stability in Xenopus egg extract.
    Methods Mol Biol. 2011;745:437-45.

  8. Cosentino C, Grieco D, Costanzo V.
    ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair.
    EMBO J. 2011 Feb 2;30(3):546-55. Epub 2010 Dec 14.

  9. Hashimoto Y, Ray Chaudhuri A, Lopes M, Costanzo V.
    Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis.
    Nat Struct Mol Biol. 2010 Nov;17(11):1305-11. Epub 2010 Oct 10.

  10. Balestrini A, Cosentino C, Errico A, Garner E, Costanzo V.
    GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication.
    Nat Cell Biol. 2010 May;12(5):484-91. Epub 2010 Apr 11.

  11. Errico A, Costanzo V.
    Differences in the DNA replication of unicellular eukaryotes and metazoans: known unknowns.
    EMBO Rep. 2010 Apr;11(4):270-8. Epub 2010 Feb 26. Review.

  12. Errico A, Cosentino C, Rivera T, Losada A, Schwob E, Hunt T, Costanzo V.
    Tipin/Tim1/And1 protein complex promotes Pol alpha chromatin binding and sister chromatid cohesion.
    EMBO J. 2009 Dec 2;28(23):3681-92. Epub 2009 Nov 5.

  13. Costanzo V, Chaudhuri J, Fung JC, Moran JV.
    Dealing with dangerous accidents: DNA double-strand breaks take centre stage. Symposium on Genome Instability and DNA Repair.
    EMBO Rep. 2009 Aug;10(8):837-42. Epub 2009 Jul 17. Review. No abstract available.

  14. Smith E, Costanzo V.
    Responding to chromosomal breakage during M-phase: insights from a cell-free system.
    Cell Div. 2009 Jul 14;4:15.

  15. Garner E, Costanzo V.
    Studying the DNA damage response using in vitro model systems.
    DNA Repair (Amst). 2009 Sep 2;8(9):1025-37. Epub 2009 May 23. Review.

  16. Russo I, Cosentino C, Del Giudice E, Broccoletti T, Amorosi S, Cirillo E, Aloj G, Fusco A, Costanzo V, Pignata C.
    In ataxia-teleangiectasia betamethasone response is inversely correlated to cerebellar atrophy and directly to antioxidative capacity.
    Eur J Neurol. 2009 Jun;16(6):755-9.

  17. Smith E, Dejsuphong D, Balestrini A, Hampel M, Lenz C, Takeda S, Vindigni A, Costanzo V.
    An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63.
    Nat Cell Biol. 2009 Mar;11(3):278-85. Epub 2009 Feb 1.

  18. Takaki T, Trenz K, Costanzo V, Petronczki M.


    Polo-like kinase 1 reaches beyond mitosis--cytokinesis, DNA damage response, and development.
    Curr Opin Cell Biol. 2008 Dec;20(6):650-60. Epub 2008 Nov 27. Review.

  19. Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A.
    HMGA1 protein is a novel target of the ATM kinase.
    Eur J Cancer. 2008 Nov;44(17):2668-79. Epub 2008 Sep 8.

  20. Jazayeri A, Balestrini A, Garner E, Haber JE, Costanzo V.
    Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity.
    EMBO J. 2008 Jul 23;27(14):1953-62. Epub 2008 Jul 3.

  21. Trenz K, Errico A, Costanzo V.
    Plx1 is required for chromosomal DNA replication under stressful conditions.
    EMBO J. 2008 Mar 19;27(6):876-85. Epub 2008 Feb 28.

  22. Errico A, Costanzo V, Hunt T.
    Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts.
    Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14929-34. Epub 2007 Sep 10.

  23. Trenz K, Smith E, Smith S, Costanzo V.
    ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks.
    EMBO J. 2006 Apr 19;25(8):1764-74. Epub 2006 Apr 6.

  24. Sobeck A, Stone S, Costanzo V, de Graaf B, Reuter T, de Winter J, Wallisch M, Akkari Y, Olson S, Wang W, Joenje H, Christian JL, Lupardus PJ, Cimprich KA, Gautier J, Hoatlin ME.
    Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks.
    Mol Cell Biol. 2006 Jan;26(2):425-37.

  25. Shechter D, Costanzo V, Gautier J.
    Regulation of DNA replication by ATR: signaling in response to DNA intermediates.
    DNA Repair (Amst). 2004 Aug-Sep;3(8-9):901-8. Review.

  26. Shechter D, Costanzo V, Gautier J.
    ATR and ATM regulate the timing of DNA replication origin firing.
    Nat Cell Biol. 2004 Jul;6(7):648-55. Epub 2004 Jun 27.

  27. Costanzo V, Paull T, Gottesman M, Gautier J.
    Mre11 assembles linear DNA fragments into DNA damage signaling complexes.
    PLoS Biol. 2004 May;2(5):E110. Epub 2004 May 11. Erratum in: PLoS Biol. 2004 Jun;2(6):876.

  28. Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J.
    An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication.
    Mol Cell. 2003 Jan;11(1):203-13.

  29. Costanzo V, Robertson K, Bibikova M, Kim E, Grieco D, Gottesman M, Carroll D, Gautier J.
    Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication.
    Mol Cell. 2001 Jul;8(1):137-47.

  30. Costanzo V, Robertson K, Ying CY, Kim E, Avvedimento E, Gottesman M, Grieco D, Gautier J.
    Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage.
    Mol Cell. 2000 Sep;6(3):649-59.