IFOM Publications Stefano Piccolo
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Selected Publications Stefano Piccolo

  1. Piccolo S, Panciera T, Contessotto P, Cordenonsi M.
    YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches.
    Nat Cancer Jan;4(1):9-26. doi: 10.1038/s43018-022-00473-z.

  2. Sladitschek-Martens HL, Guarnieri A, Brumana G, Zanconato F, Battilana G, Xiccato RL, Panciera T, Forcato M, Bicciato S, Guzzardo V, Fassan M, Ulliana L, Gandin A, Tripodo C, Foiani M, Brusatin G, Cordenonsi M, Piccolo S
    YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING.
    Nature Jul;607(7920):790-798. doi: 10.1038/s41586-022-04924-6.

  3. Piccolo S, Sladitschek-Martens HL, Cordenonsi M.
    Mechanosignaling in vertebrate development.
    Dev Biol.Aug;488:54-67. doi: 10.1016/j.ydbio.2022.05.005.

  4. Battilana, G., Zanconato, F., and Piccolo, S. (2021).
    Mechanisms of YAP/TAZ transcriptional control.
    Cell Stress 5, 167-172. 10.15698/cst2021.11.258.

  5. Castellan, M., Guarnieri, A., Fujimura, A., Zanconato, F., Battilana, G., Panciera, T., Sladitschek, H.L., Contessotto, P., Citron, A., Grilli, A., Romano O, Bicciato S, Fassan M, Porcù E, Rosato A, Cordenonsi M and Piccolo S. (2021)
    Single-cell analyses reveal YAP/TAZ as regulators of stemness and cell plasticity in Glioblastoma.
    Nat Cancer 2, 174-188. 10.1038/s43018-020-00150-z.

  6. Rajewsky, N., Almouzni, G., Gorski, S.A., Aerts, S., Amit, I., Bertero, M.G., Bock, C., Bredenoord, A.L., Cavalli, G., Chiocca, S., Piccolo S., et al. (2020).
    LifeTime and improving European healthcare through cell-based interceptive medicine.
    Nature 587, 377-386. 10.1038/s41586-020-2715-9.

  7. Panciera T, Citron A, Di Biagio D, Battilana G, Gandin A, Giulitti S, Forcato M, Bicciato S, Panzetta V, Fusco S, Azzolin L, Totaro A, Dei Tos AP, Fassan M, Vindigni V, Bassetto F, Rosato A, Brusatin G, Cordenonsi M, Piccolo S.
    Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties.
    Nat Mater. 2020 Feb 17. doi: 10.1038/s41563-020-0615-x.

  8. Totaro A, Zhuang Q, Panciera T, Battilana G, Azzolin L, Brumana G, Gandin A, Brusatin G, Cordenonsi M, Piccolo S.
    Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ mechanotransduction.
    Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17848-17857. doi: 10.1073/pnas.1908228116.

  9. Zanconato F, Cordenonsi M, Piccolo S
    YAP and TAZ: a signalling hub of the tumour microenvironment.
    Nat Rev Cancer. 2019 Aug;19(8):454-464. doi: 10.1038/s41568-019-0168-y.

  10. Chang L, Azzolin L, Di Biagio D, Zanconato F, Battilana G, Lucon Xiccato R, Aragona M, Giulitti S, Panciera T, Gandin A, Sigismondo G, Krijgsveld J, Fassan M, Brusatin G, Cordenonsi M, Piccolo S
    The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ.
    Nature (2018) 563(7730):265-269.

  11. Brusatin G, Panciera T, Gandin A, Citron A, Piccolo S
    Biomaterials and engineered microenvironments to control YAP/TAZ-dependent cell behaviour.
    Nat Mater. (2018) 17(12):1063-1075.

  12. Zanconato F, Battilana G, Forcato M, Filippi L, Azzolin L, Manfrin A, Quaranta E, Di Biagio D, Sigismondo G, Guzzardo V, Lejeune P, Haendler B, Krijgsveld J, Fassan M, Bicciato S, Cordenonsi M, Piccolo S
    Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4.
    Nat Med. (2018) 24(10):1599-1610.

  13. Totaro A, Panciera T, Piccolo S.
    YAP/TAZ upstream signals and downstream responses.
    Nat Cell Biol. (2018) 20(8):888-899

  14. Panciera T, Azzolin L, Di Biagio D, Totaro A, Cordenonsi M, Piccolo S.
    De Novo Generation of Somatic Stem Cells by YAP/TAZ.
    J Vis Exp. (2018) 7;(135).

  15. Totaro A, Castellan M, Di Biagio D, Piccolo S
    Crosstalk between YAP/TAZ and Notch Signaling.
    Trends Cell Biol. (2018) 28(7):560-573.

  16. Ingallina E, Sorrentino G, Bertolio R, Lisek K, Zannini A, Azzolin L, Severino LU, Scaini D, Mano M, Mantovani F, Rosato A, Bicciato S, Piccolo S, Del Sal G.
    Mechanical cues control mutant p53 stability through a mevalonate-RhoA axis.
    Nat Cell Biol. (2018) 20(1):28-35.

  17. Yui S, Azzolin L,Maimets M, Pedersen MT,Fordham RP, Hansen SL, Larsen HL,Guiu J, Alves MRP, Rundsten CF,Johansen JV, Li Y, Madsen CD, Nakamura T, Watanabe M, Nielsen OH, Schweiger PJ, Piccolo S, Jensen KB.
    YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration.
    Cell Stem Cell (2018) 22(1):35-49.

  18. Totaro A, Castellan M, Battilana G, Zanconato F, Azzolin L, Giulitti S, Cordenonsi M, Piccolo S.
    YAP/TAZ link cell mechanics to Notch signaling to control epidermal stem cell fate.
    Nat Commun (2017), 8:15206

  19. Azzolin L and Piccolo S
    A TIAM double hit to destruct YAP/TAZ.
    Cancer Cell (2017) 31(5):607-608

  20. Panciera T, Azzolin L, Cordenonsi M, Piccolo S
    Mechanobiology of YAP and TAZ in physiology and disease.
    Nat Rev Mol Cell Biol (2017) 18(12):758-770.

  21. Panciera T, Azzolin L, Fujimura A, Di Biagio D, Frasson C, Bresolin S, Soligo S, Basso G, Bicciato S, Rosato A, Cordenonsi M, Piccolo S
    Induction of Exandable Tissue-Specific Stem/Progenitor Cells through Transient Expression of YAP/TAZ
    Cell Stem Cell. 2016 Sep 9. pii: S1934-5909(16)30256-9. doi: 10.1016/j.stem.2016.08.009.

  22. Zanconato F, Cordenonsi M, Piccolo S
    YAP/TAZ at the Roots of Cancer.
    Cancer Cell 29, 783-803.

  23. Zanconato F, Battilana G, Cordenonsi M, Piccolo S
    YAP/TAZ as therapeutic targets in cancer.
    Curr Opin Pharmacol. 29, 26-33.

  24. Nowell CS, Odermatt PD, Azzolin L, Hohnel S, Wagner EF, Fantner GE, Lutolf MP, Barrandon Y, Piccolo S, Radtke F.
    Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction.
    Nat Cell Biol. 18, 168-80.

  25. Zanconato F, Forcato M, Battilana G, Azzolin L, Quaranta E, Bodega B, Rosato A, Bicciato S, Cordenonsi M, Piccolo S.
    Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth.
    Nat Cell Biol.17, 1218-27.

  26. Piccolo S.
    Twists of fate
    Sci Am. 311, 74-81.

  27. Piccolo S Dupont S, Cordenonsi M.
    The biology of YAP/TAZ: hippo signaling and beyond.
    Physiol Rev. 94, 1287-312.

  28. Sorrentino G, Ruggeri N, Specchia V, Cordenonsi M, Mano M, Dupont S, Manfrin A, Ingallina E, Sommaggio R, Piazza S, Rosato A, Piccolo S, Del Sal G.
    Metabolic control of YAP and TAZ by the mevalonate pathway.
    Nat Cell Biol. 16, 357-66

  29. Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, Bresolin S, Frasson C, Basso G, Guzzardo V, Fassina A, Cordenonsi M, Piccolo S
    YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response
    Cell 1, 157-70.

  30. Aragona M, Panciera T, Manfrin A, Giulitti S, Michielin F, Elvassore N, Dupont S, Piccolo S
    A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors.
    Cell 5, 1047-59

  31. Azzolin L, Zanconato F, Bresolin S, Forcato M, Basso G, Bicciato S, Cordenonsi M, Cordenonsi M, and Piccolo S (2012)
    Role of TAZ in Wnt signaling.
    Cell 7, 1443-56

  32. Inui M, Montagner M, Ben-Zvi D, Martello G, Soligo S, Manfrin A, Aragona M, Enzo E, Zacchigna L, Zanconato F, Azzolin L, Dupont S, Cordenonsi M, Piccolo S
    Self-regulation of the head-inducing properties of the Spemann organizer.
    Proc Natl Acad Sci U S A. 18 38, 15354-9

  33. Halder G, Dupont S, and Piccolo S (2012)
    Transduction of mechanical and cytoskeletal cues by Yap and TAZ.
    Nature Reviews in Molecular and Cell Biology 9, 591-600

  34. Montagner M, Enzo E, Forcato M, Zanconato F, Parenti A, Rampazzo E, Basso G, Leo G, Rosato A, Bicciato S, Cordenonsi M and Piccolo S (2012).
    Sharp1 suppresses breast cancer metastasis by promoting degradation of HIFs/hypoxia-inducible factors.
    Nature 487, 380-4

  35. Cordenonsi M, Zanconato F, Azzolin L, Forcato M, Rosato A, Frasson C, Inui M, Montagner M., Parenti A, Poletti A, Daidone MG, Dupont S, Basso G, Bicciato S, and Piccolo S (2011).
    The Hippo Transducer TAZ Confers Cancer Stem Cell-related Traits on Breast Cancer Cells.
    Cell 147, 759-72

  36. Inui M, Manfrin A, Mamidi A, Martello G, Morsut L, Soligo S, Enzo E, Moro S, Polo S, Dupont S, Cordenonsi M, and Piccolo S (2011).
    USP15 is a deubiquitylating enzyme for receptor-activated SMADs.
    Nat Cell Biol. 13, 1368-75

  37. Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Zanconato F, Le Digabel J, Forcato M, Elvassore N and Piccolo S (2011).
    Role of YAP/TAZ in mechanotransduction.
    Nature 474: 179-183

  38. Martello G, Rosato A, Ferrari F, Manfrin A, Cordenonsi M, Dupont S, Enzo E, Guzzardo V, Rondina M, Spruce T, Parenti AR, Daidone MG, Bicciato S and Piccolo S (2010)
    A microRNA targeting Dicer for metastasis control.
    Cell 141, 1195-1207

  39. Morsut L, Enzo E, Aragona M, Soligo S, Dupont S, Bressan G, Chambon P, Losson R, and Piccolo S (2010).
    Negative control of Smad activity by Ectodermin/Tif1g patterns the mammalian embryo.
    Development 137, 2571-2578

  40. Inui M, Martello G and Piccolo S (2010).
    microRNA control of signal transduction.
    Nature Reviews in Molecular Cell Biology 11, 252-63

  41. Adorno M, Cordenonsi M, Montagner M, Dupont S, Wong C, Hann B, Solari A, Parenti R, Rosato A, Bicciato S, Balmain A and Piccolo S (2009)
    A mutant-p53/Smad complex opposes p63 to empower TGF-beta induced metastasis.
    Cell 137, 87-98

  42. Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, Martello M, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S, Modena M, Argenton F, Newfield S and Piccolo S (2009)
    FAM/USP9x, a deubiquitinating enzyme essential for TGF-beta signaling controls Smad4 monoubiquitination.
    Cell 136, 123-135

  43. Martello G, Zacchigna L, Inui M, Montagner M, Adorno M, Mamidi A, Morsut L, Soligo S, Tran U, Dupont S, Cordenonsi M, Wessely O and Piccolo S (2007)
    MicroRNA control of Nodal signalling.
    Nature 449:183-8

  44. Cordenonsi M, Montagner M, Adorno M, Zacchigna L, Martello G, Mamidi A, Soligo S, Dupont S, and Piccolo S (2007)
    Integration of TGF-β and Ras/MAPK signaling through p53 phosphorylation.
    Science 315:840-3.

  45. Zacchigna, L.1, Vecchione, C., Notte, A., Cordenonsi1, M., Dupont1, S., Maretto1, S., Cifelli, G., Ferrari, A., Maffei, A., Fabbro, C., Braghetta, P., Marino, G., Selvetella, G., Aretini, A., Colonnese, C., Bettarini, U., Russo, G., Soligo, S., Adorno, M., Bonaldo, P., Volpin, D., Piccolo#, S., Lembo, G., and G. M. Bressan# (2006).
    Emilin1, a cysteine-richglycoprotein of elastic fibers, is required for blood pressurehomeostasis by regulating TGF-β maturation (2006).
    Cell 124, 929-42
    # corresponding author,
    1 SP lab

  46. Dupont, S., Zacchigna, L., Cordenonsi, M., Soligo, S., Adorno, M., Rugge, M., and Piccolo S. (2005).
    Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase.
    Cell 121, 87-99.

  47. Cordenonsi, M., Dupont, S., Maretto, S., Insinga, A., Imbriano, C., and Piccolo S (2003).
    Links between tumor suppressors: p53 is required for TGF-β gene responses by cooperating with Smads.
    Cell 113, 301-314.

  48. Maretto, S., Cordenonsi, M., Dupont, S., Braghetta, P., Broccoli, V., Hassan, A. B., Volpin, D., Bressan, G. M., and Piccolo S (2003).
    Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors.
    Proc Natl Acad Sci U S A 100, 3299-3304.

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