Pier Giorgio Mastroberardino Lab
Pier Giorgio Mastroberardino
Pier Giorgio Mastroberardino received his PhD from the University of Rome “Tor Vergata” under the supervision of Mauro Piacentini, PhD. In the initial phases of his career, he studied the contribution of the crosslinking enzyme transglutaminase 2 in the formation of aggregates in Huntington’s diseases and in the regulation of mitochondrial metabolism. In 2003, he moved to Emory University, Atlanta, GA, USA, where he entered the field of Parkinson’s disease working under the supervision of Tim Greenamyre, MD, PhD. At Emory, Pier Giorgio studied bioenergetic and redox metabolism in Parkinson’s disease.
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Genome instability and metabolism reprogramming in aging
Pier Giorgio Mastroberardino scientific interests revolve around the biology of the nervous system and its alterations in aging and related diseases, for instances neurodegenerative disorders and cancer. He originally investigated the role of cross-linking enzymes in the formation of pathological aggregates in Huntington’s disease. Subsequently, his research focus extended to the interplay between two very fundamental aspects of cell biology - metabolism and preservation of the genetic information - in health and disease.
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Recent publications
- Milanese, C., Gabriels, S., Barnhoorn, S., Cerri, S., Ulusoy, A., Gornati, S.V., Wallace, D.F., Blandini, F., Di Monte, D.A., Subramaniam, V.N., Mastroberardino, P.G.
Gender biased neuroprotective effect of Transferrin Receptor 2 deletion in multiple models of Parkinson’s disease
(2020) Cell Death and Differentiation. DOI: 10.1038/s41418-020-00698-4 - Milanese, C., Bombardieri, C.R., Sepe, S., Barnhoorn, S., Payán-Goméz, C., Caruso, D., Audano, M., Pedretti, S., Vermeij, W.P., Brandt, R.M.C., Gyenis, A., Wamelink, M.M., de Wit, A.S., Janssens, R.C., Leen, R., van Kuilenburg, A.B.P., Mitro, N., Hoeijmakers, J.H.J., Mastroberardino, P.G.
DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering
(2019) Nature Communications, 10 (1), art. no. 4887. DOI: 10.1038/s41467-019-12640-5 - Milanese, C., Mastroberardino, P.G.
A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance
(2020) Molecular and Cellular Oncology, 7 (3), art. no. 1733383. DOI: 10.1080/23723556.2020.1733383
Group members
Post doc
Chiara MilanesePhd Student
Federica TerraneoGuest researcher
Daisy SprovieroUndergraduate Student
Golsa Barid Latif(update: Nov 2021)