IFOM Publications Valter Longo
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Publications Valter Longo


  1. Caffa I, Longo VD, Nencioni A.
    Fasting plus tyrosine kinase inhibitors in cancer.
    Aging (Albany NY). 2015 Dec;7(12):1026-7. PMID: 26645151

  2. Mirzaei H, Raynes R, Longo VD.
    The conserved role of protein restriction in aging and disease.
    Curr Opin Clin Nutr Metab Care. 2016 Jan;19(1):74-9. doi: 10.1097/MCO.0000000000000239. PMID: 26560522

  3. Hirschey MD, DeBerardinis? RJ, Diehl AM, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell? E, Mehrmohamadi M, Michelotti G, Muralidhar V, Murphy MP, Pedersen PL, Poore B, Raffaghello L, Rathmell JC, Sivanand S, Vander Heiden MG, Wellen KE;
    Target Validation Team. Dysregulated metabolism contributes to oncogenesis.
    Semin Cancer Biol. 2015 Dec;35 Suppl:S129-50. doi: 10.1016/j.semcancer.2015.10.002. Epub 2015 Oct 8.PMID: 26454069

  4. Brandhorst S Cl, Cheng C, Wei M, Sedrakyan S, Navarre G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Longo VD.
    A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.
    Cell Metab. 2015 Jul 7;22(1):86-99. doi: 10.1016/j.cmet.2015.05.012. Epub 2015 Jun 18. PMID: 26094889

  5. Guevara-Aguirre J, Rosenbloom AL, Balasubramanian P, Teran E, Guevara-Aguirre M, Guevara C, Procel P, Alfaras I, De Cabo R, Di Biase S, Narvaez L, Saavedra J, Longo VD.
    GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity.
    J Clin Endocrinol Metab. 2015 Jul;100(7):2589-96. doi: 10.1210/jc.2015-1678. Epub 2015 May 18. PMID: 25985182

  6. Caffa I, D'Agostino V, Damonte P, Soncini D, Cea M, Monacelli F, Odetti P, Ballestrero A, Provenzani A, Longo VD, Nencioni A.
    Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition.
    Oncotarget. 2015 May 20;6(14):11820-32. PMID: 25909220

  7. Bianchi G, Martella R, Ravera S, Marini C, Capitanio S, Orengo A, Emionite L, Lavarello C, Amaro A, Petretto A, Pfeffer U, Sambuceti G, Pistoia V, Raffaghello L, Longo VD.
    Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models.
    Oncotarget. 2015 May 20;6(14):11806-19. PMID: 25909219

  8. Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L.
    Interventions to slow aging in humans: are we ready?
    Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22. PMID: 25902704

  9. Shim HS, Wei M, Brandhorst S, Longo VD.
    Starvation promotes REV1 SUMOylationand p53-dependent sensitization of melanoma and breast cancer cells.
    Cancer Res. 2015 Mar 15;75(6):1056-67. doi: 10.1158/0008-5472.CAN-14-2249. Epub 2015 Jan 22

  10. Shim HS, Longo VD.
    A protein restriction-dependent sulfar code for longevity.
    Cell. 2015 Jan 15;160(1-2):15-7. doi: 10.1016/j.cell.2014.12.027.PMID: 25594171

  11. Mattson MP, Allison DB, Fontana L, Harvie M, Longo VD, Malaisse WJ, Mosley M, Notterpek L, Ravussin E, Scheer FA, Syefried TN, Varady KA, Panda S.
    Meal frequency and timing in health and disease.
    Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16647-53. doi: 10.1073/pnas.1413965111. Epub 2014 Nov 17. PMID: 25404320

  12. Mirzaei H, Suarez JA, Longo VD
    Protein and amino acid restriction, aging and disease: from yeast to humans.
    Trends Endocrinol Metab. 2014 Nov;25(11):558-66. doi: 10.1016/j.tem.2014.07.002. Epub 2014 Aug 19. PMID: 25153840

  13. Fontana L, Kennedy BK, Longo VD.
    Medical research: treat ageing.
    Nature. 2014 Jul 24;511(7510):405-7. doi: 10.1038/511405a.PMID: 25056047

  14. Chia-Wei Cheng, Gregor B. Adams, Laura Perin, Min Wei, Xiaoying Zhou, Ben S. Lam, Stefano Da Sacco, Mario Mirisola, David I. Quinn, Tanya B. Dorff, John J. Kopchick, and Longo VD.
    Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression.
    Cell Stem Cell, 2014, June 5, 14

  15. Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo VD.
    Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.
    Cell Metab. 2014;19(3):407-17. PMID: 24606898. PMCID: 3988204

  16. Longo VD, Mattson MP.
    Fasting: Molecular Mechanisms and Clinical Applications.
    Cell Metab. 2014 Feb. 4;19(2):181-192.doi 10.1016 PMID:24440038

  17. Mirosola MG, Taormina G, Fabrizio P, Wei M, Hu J, Longo VD.
    Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging.
    PLos Genet. 2014 Feb. 6;10 (2):e1004113. Doi: 10.1371 PMID 24516402

  18. Longo VD, Shadel GS, Kaeberlein M, Kennedy B.
    Replicative and chronological aging in Saccharomyces cerevisiae.
    Cell Metab. 2012 Jul 3;16(1):18-31.PMID:22768836 [PubMed - in process]

  19. Lee C, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Martin-Montalvo A, Pistoia V, Wei M, Hwang S, Merlino A, Emionite L, de Cabo R, Longo VD.
    Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy.
    Sci Transl Med. 2012 Mar 7;4(124):124ra27. Epub 2012 Feb 8. PMID: 22323820

  20. Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD.
    Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer and diabetes in humans.
    Science Transl Med. 2011 Feb 16;3(70): PMID: 21325617

  21. Michán S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, Sinclair DA, Baudry M, de Cabo R, Longo VD.
    SIRT1 is essential for normal cognitive function and synaptic plasticity.
    Journal of Neuroscience, 2010, Jul 21 (29):9695-707. PMID: 20660252

  22. Fabrizio P, Hoon S, Shamalnasab M, Galbani A, Wei M, Giaever G, Nislow C, Longo VD.
    Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.
    PLoS Genetics, 2010, Jul 15; 6 (7). PMID: 20657825

  23. Fontana, L, Partridge, L., Longo VD.
    Extending the Healthy Life span: from yeast to humans.
    Science, April 16, 328, 321-6.PMID: 20395504

  24. Lee, C., Safdie, F., Raffaghello, L., Wei, M., Madia, F., Parrella, E., Hwang, D., Cohen, P.,Bianchi, G., and Longo VD.
    Reduced IGF-I levels differentially protects normal and cancer cells in response to fasting and improves chemotherapeutic index in mice.
    Cancer Research 2010 Feb 15;70(4):1564-72. PMID: 20145127

  25. Safdie FM, Dorff T, Quinn D, Fontana L, Wei M, Lee C, Cohen P, Longo VD.
    Fasting and Cancer Treatment in Humans. A case series report.
    Aging. 2009, 1(12): 988-1007. PMID: 20157582

  26. Wei, M., Fabrizio, P., Hu, Ge, H., Cheng, C., Li, L., and Longo VD.
    Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension.
    PLoS Genetics. May 2009. PMID: 19424415

  27. Madia, F., Gattazzo, C., Wei M., Weinberger, M., Nguyen, C., Huey, S., Jia H. and Longo VD.
    Oncogene homolog Sch9 promotes age-dependent genomic instability by a superoxide and Rev1-dependent mechanism.
    Journal of Cell Biology, 2009, August 24, 186, 509-23. PMID: 19687253

  28. Longo VD., Lieber, M., and Vijg, J.
    Turning Anti-aging genes against Cancer.
    Nature Reviews Molecular Cell Biology, Nov. 2008, 902. PMID: 18946478

  29. Li Y., Xu W., McBurney MW and Longo VD.
    SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons against oxidative damage.
    Cell Metabolism, 2008, 838-48. PMID: 18590691

  30. Raffaghello, L., Lee, C., Safdie, F.M., Wei, M., Madia, F., Gonidakis, S., Bianchi, G., and Longo VD.
    Starvation-dependent Differential Stress Resistance Protects Normal but not Cancer Cells Against High Dose Oxidants/Chemotherapy.
    PNAS, 2008 Mar 3.

  31. Madia F., Gattazzo C., Fabrizio P., Wei M., Nguyen C., Huey S., and Longo VD.
    Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system.
    Journal of Cell Biology, 2008 Jan 14, 67-81. PMID: 18195102

  32. Wei, M., Fabrizio, P., Hu, Ge, H., Li, L., and Longo VD.
    Life span extension by calorie restriction in Saccharomyces cerevisiae depends on Rim15 and stress response transcription factors regulated by Ras-cAMP-PKA/Sch9/Tor'.
    PLoS Genetics, 2008 Jan 4. PMID:18225956

  33. Longo, VD and Kennedy, BK.
    Sirtuins in aging and age-related disease.
    Cell. 2006 Jul 28;126 (2):257-68. PMID: 16873059

  34. Fabrizio, P, Gattazzo, C., Battistella, L., Wei, M., Cheng, C., and Longo VD.
    Sir2 Blocks Extreme Life Span Extension.
    Cell, 123, 2005, 1-13. PMID: 16286010

  35. Fabrizio, P., Battistella, L., Vardavas, R., Gattazzo, C., Liou, LL., Gralla, EB., Diaspro, A., and Longo VD.
    Superoxide is a Mediator of an Altruistic Aging program in S. cerevisiae.
    Journal of Cell Biology, 2004. 1055-1067. PMID: 15452146

  36. Longo, VD, Finch CE.
    Evolutionary Medicine: from Starvation and Dwarf Model Systems to Healthy Centenarians?
    Science 299, 2003, pp. 1342-1346. PMID: 12610293

  37. Fabrizio, P, Liou, LL., Moy, V., Valentine, J.S., Gralla, E.B., and Longo VD.
    SOD2 functions downstream of Sch9 to Extend Life Span in Yeast.
    Genetics, 163, 2003, 35-46. PMID: 12586694

  38. Xie Z, Wei M, Morgan TE, Fabrizio P, Han D, Finch CE, Longo VD.
    Peroxynitrite Mediates the Neurotoxicity of LPS or AB1-42 Activated Microglia.
    Journal of Neuroscience, 2002. 22 (9): 3484-3492. PMID: 11978825

  39. Fabrizio, P, Pozza F., Pletcher, S., Gendron, C.M., and Longo VD.
    Regulation of Longevity and Stress Resistance by Sch9 in Yeast.
    Science, 2001. 292, 288-290. PMID: 11292860
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