Dana Branzei Lab

Dana Branzei

Rumena, biologa molecolare, Dana Branzei dirige presso IFOM il Laboratorio dedicato allo studio dei meccanismi di riparazione del DNA.
Già giovanissima, grazie anche al suo mentore - un medico farmacologo che la accompagna nei primi anni del percorso di formazione - scopre la sua vocazione per la chimica. scopri di più

Contatta il ricercatore

Meccanismi di riparazione del DNA

Ricostruire il processo di riparazione del genoma nel corso della duplicazione delle cellule e, quindi, capire in che modo "si aggiusta" dalle lesioni che si possono verificare durante il processo di copiatura dei filamenti di DNA presenti nel nucleo: questo l'obiettivo del programma di ricerca condotto da Dana Branzei. scopri di più

Sede Laboratorio: Milano, Italia

Pubblicazioni recenti

Psakhye I, Kawasumi R, Abe T, Hirota K, Branzei D.
PCNA recruits cohesin loader Scc2 to ensure sister chromatid cohesion.
Nat Struct Mol Biol. 2023 Aug 17. doi: 10.1038/s41594-023-01064-x. Online ahead of print. PMID: 37592094
Joseph CR, Dusi S, Giannattasio M, Branzei D.
Rad51-mediated replication of damaged templates relies on monoSUMOylated DDK kinase.
Nat Commun. 2022 May 5;13(1):2480. doi: 10.1038/s41467-022-30215-9. PMID: 35513396; PMCID: PMC9072374.
Dolce V, Dusi S, Giannattasio M, Joseph CR, Fumasoni M, Branzei D.
Parental histone deposition on the replicated strands promotes error-free DNA damage tolerance and regulates drug resistance
Genes Dev. 2022 Feb 1;36(3-4):167-179. doi: 10.1101/gad.349207.121. Epub 2022 Feb 3. PMID: 35115379; PMCID: PMC8887126.
Kannan A, Cuartas J, Gangwani P, Branzei D, Gangwani L.
Mutation in senataxin alters the mechanism of R-loop resolution in amyotrophic lateral sclerosis 4
Brain. 2022 Sep 14;145(9):3072-3094. doi: 10.1093/brain/awab464. PMID: 35045161; PMCID: PMC9536298.
Humphreys IR, Pei J, Baek M, Krishnakumar A, Anishchenko I, Ovchinnikov S, Zhang J, Ness TJ, Banjade S, Bagde SR, Stancheva VG, Li XH, Liu K, Zheng Z, Barrero DJ, Roy U, Kuper J, Fernández IS, Szakal B, Branzei D, Rizo J, Kisker C, Greene EC, Biggins S, Keeney S, Miller EA, Fromme JC, Hendrickson TL, Cong Q, Baker D.
Computed structures of core eukaryotic protein complexes.
Science. 2021 Dec 10;374(6573):eabm4805. doi: 10.1126/science.abm4805. Epub 2021 Dec 10. PMID: 34762488; PMCID: PMC7612107.
Kawasumi R, Abe T, Psakhye I, Miyata K, Hirota K, Branzei D.
Vertebrate CTF18 and DDX11 essential function in cohesion is bypassed by preventing WAPL-mediated cohesin release.
Genes Dev. 2021 Oct 1;35(19-20):1368-1382. doi:10.1101/gad.348581.121. Epub 2021 Sep 9. PMID: 34503989; PMCID: PMC8494208.
Psakhye I, Branzei D.
SMC complexes are guarded by the SUMO protease Ulp2 against SUMO-chain-mediated turnover.
Cell Rep. 2021 Aug 3;36(5):109485. doi:10.1016/j.celrep.2021.109485. PMID: 34348159.
Branzei D, Szakal B.
DNA helicases in homologous recombination repair
Curr Opin Genet Dev. 2021 Dec;71:27-33. doi: 10.1016/j.gde.2021.06.009. Epub 2021 Jul 14. PMID: 34271541.
Jegadesan NK, Branzei D.
DDX11 loss causes replication stress and pharmacologically exploitable DNA repair defects
Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2024258118. doi: 10.1073/pnas.2024258118. PMID: 33879618; PMCID: PMC8092582.
Agashe S, Joseph CR, Reyes TAC, Menolfi D, Giannattasio M, Waizenegger A, Szakal B, Branzei D.
Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites.
Nat Commun. 2021 Apr 8;12(1):2111. doi: 10.1038/s41467-021-22217-w. PMID: 33833229; PMCID: PMC8032827.

Lista Completa PubMed Google Scholar

Membri del gruppo

Staff Scientist

Barnabas Szakal

Lab Technician

Martina Rosato

Postdoc fellows

Ivan Psakhye
Aki Nunomiya

Phd Student

Bene Szabolcs
Morea Alessandro

Research fellow

Ezgi Gül Keskin

Master Student

Nima Saeedi

Former Lab members

Shaghayegh Jafarzadeh (Master Student)
Sabrina Dusi (lab assistant)
Francesca Andriani (lab assistant)
Valeria Mastrodonato (postdoc)
Nanda Kumar Jegadesan (PhD student)
Valeria Dolce (PhD student)
Chinnu Rose Joseph (PhD student)
Teresa Anne Clarisse Reyes (PhD student)
Anja Waizzenegger (postdoc)
Matteo Villa (postdoc)
Ryotaro Kawasumi (PhD student, postdoc)
Sumedha Agashe (PhD student)
Demis Menolfi (Master student, PhD student, postdoc)
Marco Fumasoni (Master student, PhD student, postdoc)
Federica Castellucci (PhD student, postdoc)
Saho Era (PhD student)
Takuya Abe (postdoc)
Madhusoodanan Urulangodi (postdoc)
Victor Gonzalez-Huici (postdoc)
Marek Sebesta (postdoc)
Fabio Vanoli (postdoc)
Julie Sollier (postdoc)
Eerappa Rajakumara (postdoc)
Livia Provitera (postdoc)
Teresa Anne Clarisse Reyes (Master student)
Beatrice Toia (Master student)
Alexandra Mayer (postdoc)
Francesco Rossi (PhD student, postdoc)

(update: Sep 2023)

IFOM Review

Seeing is believing: catching template-switching in the act

Commentary on Dana Branzei's paper published on Nature Structural & Molecular Biology, by Michael Lichten (2015)

complete review

Rassegna Stampa

Quelli che decidono di restare in Italia

2016.02.17

Il Corriere della Sera | G.Caprara, A. De Gregorio, V. Santarpia

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Rassegna Stampa del ricercatore